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. 1975 Sep;72(9):3697–3700. doi: 10.1073/pnas.72.9.3697

Oncornavirus-like particles in human skin cancers.

B R Balda, R Hehlmann, J R Cho, S Spiegelman
PMCID: PMC433064  PMID: 52874

Abstract

A high-molecular-weight RNA encapsulated with an RNA-instructed DNA polymerase in particles possessing the density characteristic of the RNA tumor viruses has been detected in 13 out of 14 human malignant melanomas. The [3H]DNA synthesized by these particles in an endogenous reaction hybridizes to RNA extracted from the human melanoma particulate structures, but not to RNA from normal skin. Similar particles containing RNA and enzyme have been found in basal cell and squamous cell carcinomas of the skin. The RNA of the melanoma particles is easily distinguishable by hybridization from the RNAs found in the particles of the basal and squamous cell carcinomas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Axel R., Gulati S. C., Spiegelman S. Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3133–3137. doi: 10.1073/pnas.69.11.3133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Axel R., Schlom J., Spiegelman S. Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. Nature. 1972 Jan 7;235(5332):32–36. doi: 10.1038/235032a0. [DOI] [PubMed] [Google Scholar]
  3. Baxt W., Hehlmann R., Spiegelman S. Human leukaemic cells contain reverse transcriptase associated with a high molecular weight virus-related RNA. Nat New Biol. 1972 Nov 15;240(98):72–75. doi: 10.1038/newbio240072a0. [DOI] [PubMed] [Google Scholar]
  4. Birkmayer G. D., Balda B. R., Miller F., Braun-Falco O. Virus-like particles in metastases of human malignant melanoma. Naturwissenschaften. 1972 Aug;59(8):369–370. doi: 10.1007/BF00617924. [DOI] [PubMed] [Google Scholar]
  5. Birkmayer G. D., Balda B. R., Miller F. Oncorna-viral information in human melanoma. Eur J Cancer. 1974 Jul;10(7):419–424. doi: 10.1016/0014-2964(74)90024-3. [DOI] [PubMed] [Google Scholar]
  6. CHANNING A. A., KASUGA T., DEMOPOULOS H. B. VIRUS PARTICLES IN B-16 AND S-91 MOUSE MELANOMAS AND THEIR SIGNIFICANCE. Lab Invest. 1965 Feb;14:219–230. [PubMed] [Google Scholar]
  7. Cuatico W., Cho J. R., Spiegelman S. Evidence of particle-associated RNA-directed DNA polymerase and high molecular weight RNA in human gastrointestinal and lung malignancies. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3304–3308. doi: 10.1073/pnas.71.8.3304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cuatico W., Cho J. R., Spiegelman S. Particles with RNA of high molecular weight and RNA-directed DNA polymerase in human brain tumors. Proc Natl Acad Sci U S A. 1973 Oct;70(10):2789–2793. doi: 10.1073/pnas.70.10.2789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Epstein W. L., Fukuyama K., Benn M., Keston A. S., Brandt R. B. Transmission of a pigmented melanoma in golden hamsters by a cell-free ultrafiltrate. Nature. 1968 Aug 31;219(5157):979–980. doi: 10.1038/219979a0. [DOI] [PubMed] [Google Scholar]
  10. Hehlmann R., Baxt W., Kufe D., Spiegelman S. Molecular evidence for a viral etiology of human leukemias, lymphomas, and sarcomas. Am J Clin Pathol. 1973 Jul;60(1):65–79. doi: 10.1093/ajcp/60.1.65. [DOI] [PubMed] [Google Scholar]
  11. Hehlmann R., Kufe D., Spiegelman S. RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA). Proc Natl Acad Sci U S A. 1972 Feb;69(2):435–439. doi: 10.1073/pnas.69.2.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hehlmann R., Kufe D., Spiegelman S. Viral-related RNA in Hodgkins' disease and other human lymphomas. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1727–1731. doi: 10.1073/pnas.69.7.1727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kufe D., Hehlmann R., Spiegelman S. Human sarcomas contain RNA related to the RNA of a mouse leukemia virus. Science. 1972 Jan 14;175(4018):182–185. doi: 10.1126/science.175.4018.182. [DOI] [PubMed] [Google Scholar]
  14. Kufe D., Hehlmann R., Spiegelman S. RNA related to that of a murine leukemia virus in Burkitt's tumors and nasopharyngeal carcinomas. Proc Natl Acad Sci U S A. 1973 Jan;70(1):5–9. doi: 10.1073/pnas.70.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kufe D., Magrath I. T., Ziegler J. L., Spiegelman S. Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA. Proc Natl Acad Sci U S A. 1973 Mar;70(3):737–741. doi: 10.1073/pnas.70.3.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Parsons P. G., Goss P., Pope J. H. Detection in human melanoma cell lines of particles with some properties in common with RNA tumour viruses. Int J Cancer. 1974 May 15;13(5):606–618. doi: 10.1002/ijc.2910130505. [DOI] [PubMed] [Google Scholar]
  17. Schlom J., Spiegelman S. Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses. Science. 1971 Nov 19;174(4011):840–843. doi: 10.1126/science.174.4011.840. [DOI] [PubMed] [Google Scholar]

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