Table 1.
Demographic data and conventional risk factors for the study population.
| Le(a−b−) n=44 | Le(a+b−) n=58 | Le(a−b+) n=121 | p value* | p value** | |
|---|---|---|---|---|---|
|
| |||||
| Age (years) | 65.5±1.4 | 63.9±1.2 | 63.5±0.9 | 0.50 | 0.24 |
|
| |||||
| Females | 32 (73%) | 46 (79%) | 76 (63%) | 0.07 | 0.24 |
|
| |||||
| BMI (kg/m2) | 27.7±0.8 | 26.1±0.7 | 26.9±0.5 | 0.28 | 0.43 |
|
| |||||
| Fasting glucose (mg/dL) | 98.7±1.7 | 95.3±1.5 | 97.7±1.0 | 0.25 | 0.62 |
|
| |||||
| Total cholesterol (mg/dL) | 214.2±5.4 | 223.7±4.7 | 215.3±3.2 | 0.28 | 0.86 |
|
| |||||
| LDL cholesterol (mg/dL) | 132.3±4.8 | 138.6±4.2 | 132.3±2.9 | 0.43 | 0.99 |
|
| |||||
| HDL cholesterol (mg/dL) | 58.8±2.5 | 63.6±2.2 | 59.1±1.5 | 0.19 | 0.93 |
|
| |||||
| Triglycerides (mg/dL) | 115.2±8.4 | 107.0±7.2 | 119.3±5.0 | 0.38 | 0.70 |
|
| |||||
| Systolic BP (mmHg) | 125.8±2.4 | 119.9±2.1 | 124.5±1.4 | 0.11 | 0.66 |
|
| |||||
| Diastolic BP (mmHg) | 75.2±1.3 | 76.1±1.1 | 76.8±0.8 | 0.57 | 0.31 |
|
| |||||
| Smoking (ex and current) | 21 (48%) | 24 (41%) | 47 (39%) | 0.61 | 0.32 |
|
| |||||
| Trial*** | |||||
| BVAIT: B-Vitamin treated | 15 (34%) | 11 (19%) | 37 (31%) | 0.15 | |
| BVAIT: Placebo treated | 11 (25%) | 14 (24%) | 38 (31%) | ||
| WISH | 18 (41%) | 33 (57%) | 46 (38%) | ||
Values in tables are mean±SEM or n (percent)
*
p value for comparison of differences among Lewis phenotype groups ANOVA or chi-square test
**
p value for comparison of Lewis(a−b−) vs. Lewis(a−b+) group using ANOVA
***
Trial distribution by Lewis phenotype frequencies, n (%), chi-square p-value