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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Atherosclerosis. 2015 Jan 21;239(1):248–251. doi: 10.1016/j.atherosclerosis.2015.01.015

Table 2.

Comparison of hemorheological profiles and inflammatory markers among individuals with different Lewis phenotypes, adjusted for age, gender, ethnicity, smoking and trial group.

Le(a−b−) n=44 Le(a+b−) n=58 Le(a−b+) n=121 p value* p value**
WBC (cell/μl)±SEM 5.65±0.25 4.97±0.23 5.22±0.20
Log WBC (cell/μl)±SEM# 1.70±0.04 1.59±0.04 1.62±0.03 0.05 0.08
Hematocrit (%)±SEM 41.88±0.48 41.54±0.44 41.86±0.38 0.74 0.98
ESR (native hct; mm/hr)±SEM 28.37±2.56 18.24±2.33 14.83±2.50
Log ESR (native hct; mm/hr)±SEM# 3.21±0.15 2.75±0.14 2.48±0.14 0.0001 0.0002
ESR (40% hct; mm/hr)±SEM 29.38±2.61 17.67±2.38 13.82±2.55
Log ESR (40% hct; mm/hr)±SEM# 3.30±0.14 2.80±0.13 2.55±0.14 <0.0001 <0.0001
M in plasma ±SEM+ 23.48±0.75 19.13±0.69 18.03±0.59
Log M in plasma ±SEM#+ 3.14±0.04 2.94±0.04 2.88±0.03 <0.0001 <0.0001
M1 in plasma ±SEM+ 35.94±1.10 28.43±1.01 26.91±0.87
Log M1 in plasma ±SEM#+ 3.57±0.04 3.34±0.04 3.28±0.03 <0.0001 <0.0001
M in dextran ±SEM+ 24.32±0.75 22.87±0.69 22.55±0.59 0.06 0.03
M1 in dextran ±SEM+ 36.72±1.00 34.38±0.92 34.43±0.79 0.05 0.03
Plasma viscosity (mPa.s)±SEM 1.67±0.01 1.60±0.01 1.58±0.01 <0.0001 <0.0001
Fibrinogen (g/L)±SEM 4.11±0.23 3.74±0.24 3.65±0.23
Log Fibrinogen (g/L)±SEM 1.38±0.06 1.30±0.06 1.27±0.06 0.16 0.10
hs-CRP (mg/L)±SEM 2.83±0.67 2.28±0.64 1.60±0.62
Log hs-CRP (mg/L)±SEM# 0.38±0.27 0.29±0.27 −0.12±0.26 0.18 0.05
Insulin (μU/mL)±SEM 13.37±1.38 11.30±1.44 9.70±1.38
Log Insulin (μU/mL)±SEM# 2.47±0.10 2.38±0.11 2.20±0.10 0.05 0.02
Homocysteine (μmol/L)±SEM 13.06±1.71 9.30±1.83 9.98±1.02
Log homocysteine (μmol/L)±SEM# 2.34±0.08 2.20±0.08 2.26±0.04 0.41 0.35
*

p value for comparison of Lewis negative vs. Lewis A vs. Lewis B groups using ANOVA

**

p value for comparison of Lewis negative vs. Lewis B group using ANOVA

+

Myrenne M value represents RBC aggregation at stasis; M1 index represents RBC aggregation at very low shear.

#

variables compared following log transformation

Number of subjects different for these parameters (na−b−/na+b−/na−b+): ESR = 19/30/29, fibrinogen = 21/25/33, hs-CRP = 31/36/53, insulin = 29/30/38; fasting homocysteine = 15/12/60