Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Oct;72(10):4177–4179. doi: 10.1073/pnas.72.10.4177

Effect of hypothalamic deafferentation on thyrotropin-releasing hormone levels in rat brain.

M J Brownstein, R D Utiger, M Palkovits, J S Kizer
PMCID: PMC433163  PMID: 812092

Abstract

The medial basal hypothalamus was isolated from the remainder of the brain of the rat using a Halász knife. Ten to 14 days after the surgical procedure the concentration of thyrotropin-releasing hormone within the island of hypothalamic tissue was 76% lower than in tissue from sham-operated control rats. Thus, much of the thyrotropin-releasing hormone that is normally present in the medial basal hypothalamus may be synthesized by cells outside of this region. There were no reductions in hormone levels in regions outside of the hypothalamic island after the surgical procedure. Extrahypothalamic thyrotropin-releasing hormone does not appear to be produced by hypothalamic neurosecretory cells.

Full text

PDF
4177

Images in this article

4178Image
on p.4178

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bassiri R. M., Utiger R. D. The preparation and specificity of antibody to thyrotropin releasing hormone. Endocrinology. 1972 Mar;90(3):722–727. doi: 10.1210/endo-90-3-722. [DOI] [PubMed] [Google Scholar]
  2. Boler J., Enzmann F., Folkers K., Bowers C. Y., Schally A. V. The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide. Biochem Biophys Res Commun. 1969 Nov 6;37(4):705–710. doi: 10.1016/0006-291x(69)90868-7. [DOI] [PubMed] [Google Scholar]
  3. Brownstein M. J., Palkovits M., Saavedra J. M., Bassiri R. M., Utiger R. D. Thyrotropin-releasing hormone in specific nuclei of rat brain. Science. 1974 Jul 19;185(4147):267–269. doi: 10.1126/science.185.4147.267. [DOI] [PubMed] [Google Scholar]
  4. Burgus R., Dunn T. F., Desiderio D., Guillemin R. Structure moléculaire du facteur hypothalamique hypophysiotrope TRF d'origine ovine: mise en évidence par spectrométrie de masse de la séquence PCA-His-Pro-NH2. C R Acad Sci Hebd Seances Acad Sci D. 1969 Nov 12;269(19):1870–1873. [PubMed] [Google Scholar]
  5. COOK W. H., WALKER J. H., BARR M. L. A cytological study of transneuronal atrophy in the cat and rabbit. J Comp Neurol. 1951 Apr;94(2):267–291. doi: 10.1002/cne.900940207. [DOI] [PubMed] [Google Scholar]
  6. GOLDBY F. A note on transneuronal atrophy in the human lateral geniculate body. J Neurol Neurosurg Psychiatry. 1957 Aug;20(3):202–207. doi: 10.1136/jnnp.20.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Glees P., le Gros Clark W. E. The termination of optic fibres in the lateral geniculate body of the monkey. J Anat. 1941 Apr;75(Pt 3):295–308.3. [PMC free article] [PubMed] [Google Scholar]
  8. HAMLYN L. H. The effect of preganglionic section on the neurons of the superior cervical ganglion in rabbits. J Anat. 1954 Apr;88(2):184–191. [PMC free article] [PubMed] [Google Scholar]
  9. Halász B., Florsheim W. H., Corcorran N. L., Gorski R. A. Thyrotrophic hormone secretion in rats after partial or total interruption of nueral afferents to the medial basal hypothalamus. Endocrinology. 1967 Jun;80(6):1075–1082. doi: 10.1210/endo-80-6-1075. [DOI] [PubMed] [Google Scholar]
  10. Halász B., Pupp L. Hormone secretion of the anterior pituitary gland after physical interruption of all nervous pathways to the hypophysiotrophic area. Endocrinology. 1965 Sep;77(3):553–562. doi: 10.1210/endo-77-3-553. [DOI] [PubMed] [Google Scholar]
  11. Jackson I. M., Reichlin S. Thyrotropin releasing hormine (TRH): distribution in the brain, blood and urine of the rat. Life Sci. 1974 Jun 1;14(11):2259–2266. doi: 10.1016/0024-3205(74)90107-6. [DOI] [PubMed] [Google Scholar]
  12. MATSUDA K., GREER M. A., DUYCK C. NEURAL CONTROL OF THYROTROPIN SECRETION: EFFECT OF FOREBRAIN REMOVAL ON THYROID FUNCTION. Endocrinology. 1963 Oct;73:462–466. doi: 10.1210/endo-73-4-462. [DOI] [PubMed] [Google Scholar]
  13. MATTHEWS M. R., POWELL T. P. Some observations on transneuronal cell degeneration in the olfactory bulb of the rabbit. J Anat. 1962 Jan;96:89–102. [PMC free article] [PubMed] [Google Scholar]
  14. Matthews M. R., Cowan W. M., Powell T. P. Transneuronal cell degeneration in the lateral geniculate nucleus of the macaque monkey. J Anat. 1960 Apr;94(Pt 2):145–169. [PMC free article] [PubMed] [Google Scholar]
  15. Oliver C., Eskay R. L., Ben-Jonathan N., Porter J. C. Distribution and concentration of TRH in the rat brain. Endocrinology. 1974 Aug;95(2):540–546. doi: 10.1210/endo-95-2-540. [DOI] [PubMed] [Google Scholar]
  16. PENMAN J., SMITH M. C. Degeneration of the primary and secondary sensory neurones after trigeminal injection. J Neurol Neurosurg Psychiatry. 1950 Feb;13(1):36–46. doi: 10.1136/jnnp.13.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. POWELL T. P., ERULKAR S. D. Transneuronal cell degeneration in the auditory relay nuclei of the cat. J Anat. 1962 Apr;96:249–268. [PMC free article] [PubMed] [Google Scholar]
  18. TORVIK A. Transneuronal changes in the inferior olive and pontine nuclei in kittens. J Neuropathol Exp Neurol. 1956 Apr;15(2):119–145. doi: 10.1097/00005072-195604000-00001. [DOI] [PubMed] [Google Scholar]
  19. Winokur A., Utiger R. D. Thyrotropin-releasing hormone: regional distribution in rat brain. Science. 1974 Jul 19;185(4147):265–267. doi: 10.1126/science.185.4147.265. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES