Abstract
Binding of methadone in body tissues limits the rise in plasma concentration and prolongs the pharmacological action in patients receiving a daily maintenance dose. An opiate with equal intrinsic activity but greater binding affinity would, therefore, be a better drug than methadone for maintenance treatment; it would be safer when taken in a single dose and longer in its duration of action when taken on a regular schedule.
Keywords: heroin, humans, opiate, maintenance treatment, addiction
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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