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. 1973 Jan;70(1):161–163. doi: 10.1073/pnas.70.1.161

The Nature of the Ground States of Cobalt(II) and Nickel(II) Carboxypeptidase A

Robert C Rosenberg *, Charles A Root *,‡, Run-Han Wang †, Massimo Cerdonio †,§, Harry B Gray *,
PMCID: PMC433206  PMID: 4509646

Abstract

The magnetic susceptibilities of cobalt(II) and nickel(II) derivaties of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 ± 0.15 and 2.53 ± 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.

Keywords: metallocarboxypeptidase A, magnetic susceptibility, coordination geometry, spectra

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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