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. 1973 Jan;70(1):235–239. doi: 10.1073/pnas.70.1.235

Immunochemical Analysis of the Cross-Reacting Idiotypes of Mouse Myeloma Proteins with Anti-Dextran Activity and Normal Anti-Dextran Antibody

Dennis Carson 1,2, Martin Weigert 1,2
PMCID: PMC433222  PMID: 4119224

Abstract

The idiotype of the mouse myeloma protein with anti-α-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with α1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.

Keywords: radioimmunoassay, hapten, light and heavy chains, mice

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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