Abstract
An octacosapeptide with the entire sequence proposed for the newly isolated vasoactive intestinal polypeptide was synthesized and had the expected biological properties. Synthetic peptides corresponding to the C-terminal hendeca-, tetradeca-, pentadeca-, and docosapeptide sequences of the vasoactive intestinal polypeptide showed activities that increased with increasing chain length.
Keywords: dog, solution synthesis, azide coupling
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown J. C., Dryburgh J. R. A gastric inhibitory polypeptide. II. The complete amino acid sequence. Can J Biochem. 1971 Aug;49(8):867–872. doi: 10.1139/o71-122. [DOI] [PubMed] [Google Scholar]
- Mutt V., Jorpes J. E., Magnusson S. Structure of porcine secretin. The amino acid sequence. Eur J Biochem. 1970 Sep;15(3):513–519. doi: 10.1111/j.1432-1033.1970.tb01034.x. [DOI] [PubMed] [Google Scholar]
- Piper P. J., Said S. I., Vane J. R. Effects on smooth muscle preparations of unidentified vasoactiv peptides from intestine and lung. Nature. 1970 Mar 21;225(5238):1144–1146. doi: 10.1038/2251144a0. [DOI] [PubMed] [Google Scholar]
- Said S. I., Mutt V. Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon. Eur J Biochem. 1972 Jul 13;28(2):199–204. doi: 10.1111/j.1432-1033.1972.tb01903.x. [DOI] [PubMed] [Google Scholar]
- Said S. I., Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970 Sep 18;169(3951):1217–1218. doi: 10.1126/science.169.3951.1217. [DOI] [PubMed] [Google Scholar]