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. 1973 Feb;70(2):521–525. doi: 10.1073/pnas.70.2.521

Terminal Deoxynucleotidyl Transferase in a Case of Childhood Acute Lymphoblastic Leukemia

Ronald McCaffrey *, Donna F Smoler *, David Baltimore *
PMCID: PMC433296  PMID: 4346893

Abstract

Cells from a patient with childhood acute lymphoblastic leukemia contain an apparent DNA polymerase activity that was not found in any other cells except thymus cells. The enzyme has the properties of terminal transferase, an enzyme known to be found in thymocytes. The cells also contain the three major DNA polymerases found in growing cells. The results suggest that these tumor cells arose from a block in the differentiation of thymocytes. Terminal transferase may be a marker for the origin of leukemic cells.

Keywords: thymocytes, DNA polymerases

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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