Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1973 Mar;70(3):817–821. doi: 10.1073/pnas.70.3.817

Chemotaxis by the Nematode Caenorhabditis elegans: Identification of Attractants and Analysis of the Response by Use of Mutants

Samuel Ward 1,*
PMCID: PMC433366  PMID: 4351805

Abstract

The nematode Caenorhabditis elegans is attracted by at least four classes of attractants: by cyclic nucleotides, cAMP and cGMP; by anions, Cl-, Br-, I-; by cations, Na+, Li+, K+, Mg+; and by alkaline pH values. The nematode's behavioral response to gradients of these attractants involves orientation and movement up the gradient, accumulation, and then habitutation. Comparison of the tracks of wild-type and mutant animals responding to gradients of attractants indicates that sensory receptors in the head alone mediate the orientation response and that the direction of orientation is determined by the lateral motion of the head. Therefore, the orientation response is a klinotaxis.

Keywords: cAMP, anions, cations, hydroxyl ions, klinotaxis

Full text

PDF
817

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler J. Chemoreceptors in bacteria. Science. 1969 Dec 26;166(3913):1588–1597. doi: 10.1126/science.166.3913.1588. [DOI] [PubMed] [Google Scholar]
  2. Benzer S. BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1112–1119. doi: 10.1073/pnas.58.3.1112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Konijn T. M., van de Meene J. G., Chang Y. Y., Barkley D. S., Bonner J. T. Identification of adenosine-3',5'-monophosphate as the bacterial attractant for myxamoebae of Dictyostelium discoideum. J Bacteriol. 1969 Aug;99(2):510–512. doi: 10.1128/jb.99.2.510-512.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Thompson R. F., Spencer W. A. Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychol Rev. 1966 Jan;73(1):16–43. doi: 10.1037/h0022681. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES