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. 1973 Mar;70(3):849–853. doi: 10.1073/pnas.70.3.849

A Crystalline Fragment of the Double Helix: The Structure of the Dinucleoside Phosphate Guanylyl-3′,5′-Cytidine

Roberta Ogilvie Day 1,*, Nadrian C Seeman 1, John M Rosenberg 1, Alexander Rich 1
PMCID: PMC433373  PMID: 4514996

Abstract

The sodium salt of guanylyl-3′,5′-cytidine crystallizes in a monoclinic unit cell with one molecule in the asymmetric unit. Each molecule is related to another molecule by a 2-fold rotation axis which results in the formation of an antiparallel, right-handed double helix with complementary hydrogen bonding between the guanine and cytosine residues. The crystal is heavily hydrated with 36 water molecules in the unit cell. The geometry of this crystalline double helix is very similar to those which have been derived from studies of fiber x-ray diffraction patterns of double-stranded RNA, even though the latter do not yield data at atomic resolution.

Keywords: x-ray diffraction, complementary hydrogen bonding, dinucleoside phosphate, right-handed helix

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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