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. 1973 Mar;70(3):859–862. doi: 10.1073/pnas.70.3.859

A Type-C Virus in Human Rhabdomyosarcoma Cells After Inoculation into NIH Swiss Mice Treated with Antithymocyte Serum

George J Todaro *,†, Paul Arnstein *,†, Wade P Parks *,†, Edwin H Lennette *, Robert J Huebner *,†
PMCID: PMC433375  PMID: 4123693

Abstract

A type-C RNA virus has been isolated that replicates readily in human and other primate cells. It was obtained from a human rhabdomyosarcoma cell (RD) that had been serially transplanted in immunosuppressed NIH Swiss mice, a strain of mouse from which infectious type-C virus has not been isolated. Various other human tumor cells, similarly transplanted, remained free of overt type-C virus expression. The virus growing in the RD cells, AT-124, has a group-specific antigen and an RNA-dependent DNA polymerase immunologically related to murine type-C viruses, but a host range similar to that of the RD-114 virus. The new isolate is either a previously undescribed, endogenous type-C virus from NIH Swiss mice or a recombinant with both mouse and human type-C genetic information.

Keywords: RNA-dependent DNA polymerase, group-specific antigen

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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