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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1973 Mar;70(3):863–864. doi: 10.1073/pnas.70.3.863

The Role of the Histocompatibility-2-Linked Ss-Slp Region in the Control of Mouse Complement

P Démant 1, Jana Capková 1, Eva Hinzová 1, Bela Vorácová 1
PMCID: PMC433376  PMID: 4514997

Abstract

The Ss-Slp region of the mouse genome is located between the two loci, H-2K and H-2D, of the major histocompatibility system. It controls the level of a serologically detectable serum globulin, the Ss protein, and its allotypic forms, Slpa and Slpo. Evidence is presented that the Ss-Slp region is involved in control of the complement system. Mice of congenic resistant strains differing only at the H-2 gene complex show differences in complement levels. A comparison of H-2 recombinants demonstrated that complement level correlates with the Ss-Slp genotype and not with the H-2K, H-2D, or Ir genotypes. Among the 13 congenic strains tested, those with the SshSlpa allele had higher complement levels than those with the SshSlpo or SslSlpo alleles. Mice with recombinant H-2 haplotypes had complement levels similar to those of the parental strain that provided the Ss-Slp segment. It was also shown that anti-Ss serum inhibits complement activity of mouse serum in vitro.

Keywords: complement level, congenic strains, H-2 recombinants

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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