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. 1973 Mar;70(3):929–933. doi: 10.1073/pnas.70.3.929

Coagulation of Blood Plasma of Guinea Pig by the Bone Matrix

Charles B Huggins 1, A H Reddi 1
PMCID: PMC433390  PMID: 4515003

Abstract

Optimal amounts of demineralized bone matrix possess the ability to coagulate platelet-free heparinized, citrated, and oxalated blood plasmas of guinea pigs. Clotting constituents become denatured in contact with the insoluble coagulant proteins. Quantities in excess of optimal modify plasma so that it does not gel when thrombin is added. The newly described coagulant effects are not restricted to the bone matrix, but are present also in the demineralized matrices of tooth and ivory, and in denatured tendon as well. They are regulated properties that were not demonstrated in mineralized bone or native tendon. The coagulant attributes of bone matrix are consistent with those of electropositive polymers of a specific sort.

Keywords: tendon collagen, [35S]heparin, citrate, hexadimethrine, fibrinogen

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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