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. 1973 Apr;70(4):1094–1098. doi: 10.1073/pnas.70.4.1094

Chromosomal Abnormalities in Spleens of New Zealand Black Mice, A Strain Characterized by Autoimmunity and Malignancy

Philip J Fialkow *, Gillian R Paton †, June East ‡
PMCID: PMC433433  PMID: 4515606

Abstract

Mosaicism of normal and chromosomally aberrant cells was detected in 14 of 20 spleens from adult New Zealand Black (NZB) mice reared under conventional conditions, a strain that spontaneously develops autoimmunity and lymphoreticular malignancy. No abnormalities were found in marrows from these same animals or in spleens from NZB mice younger than 3 months. The prevalence of chromosomal aberrations was significantly higher in spleens from NZB mice than in spleens from the two other strains studied—SJL/J, which has high frequency of reticulum cell neoplasia and paraproteinemia but no autoimmunity, and BALB/c, which has essentially no autoimmunity and only a low incidence of generalized lymphoid neoplasms and plasmacytomas in ageing animals. Causes for the chromosomal abnormalities in NZB mice are considered in terms of other features in these mice—immunoproliferation, autoimmunity, and the presence of murine leukemia (“C”-type) virus particles.

Keywords: immunoproliferation, C-type viruses

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bielschowsky M., Goodall C. M. Origin of inbred NZ mouse strains. Cancer Res. 1970 Mar;30(3):834–836. [PubMed] [Google Scholar]
  2. Cantor H., Asofsky R. Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by Balb-c lymphoid cells of differing anatomic origin. J Exp Med. 1970 Feb;131(2):235–246. doi: 10.1084/jem.131.2.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dunn T. B., Deringer M. K. Reticulum cell neoplasm, type B, or the "Hodgkin's-like lesion" of the mouse. J Natl Cancer Inst. 1968 Apr;40(4):771–821. [PubMed] [Google Scholar]
  4. East J., Branca M. Autoimmune reactions and malignant changes in germ-free New Zealand Black mice. Clin Exp Immunol. 1969 Jun;4(6):621–635. [PMC free article] [PubMed] [Google Scholar]
  5. East J. Immunopathology and neoplasms in New Zealand black (NZB) and SJL-J mice. Prog Exp Tumor Res. 1970;13:84–134. doi: 10.1159/000386038. [DOI] [PubMed] [Google Scholar]
  6. FIALKOW P. J. AUTOIMMUNITY: A PREDISPOSING FACTOR TO CHROMOSOMAL ABERRATIONS? Lancet. 1964 Feb 29;1(7331):474–475. doi: 10.1016/s0140-6736(64)90803-7. [DOI] [PubMed] [Google Scholar]
  7. Fialkow P. J. "Immunologic" oncogenesis. Blood. 1967 Sep;30(3):388–394. [PubMed] [Google Scholar]
  8. Halpern B., Emerit I., Housset E., Feinglod J. Possible autoimmune processes related to chromosomal abnormalities (breakage) in NZB mice. Nat New Biol. 1972 Feb 16;235(59):214–215. doi: 10.1038/newbio235214a0. [DOI] [PubMed] [Google Scholar]
  9. Leventhal B. G., Talal N. Response of NZB and NZB-NZW spleen cells to mitogenic agents. J Immunol. 1970 Apr;104(4):918–923. [PubMed] [Google Scholar]
  10. McIntire K. R., Law L. W. Abnormal serum immunoglobulins occurring with reticular neoplasms in a inbred strain of mouse. J Natl Cancer Inst. 1967 Dec;39(6):1197–1211. [PubMed] [Google Scholar]
  11. Schwartz R. S., Beldotti L. Malignant lymphomas following allogenic disease: transition from an immunological to a neoplastic disorder. Science. 1965 Sep 24;149(3691):1511–1514. doi: 10.1126/science.149.3691.1511. [DOI] [PubMed] [Google Scholar]
  12. Shirai T., Mellors R. C. Natural thymocytotoxic autoantibody and reactive antigen in New Zealand black and other mice. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1412–1415. doi: 10.1073/pnas.68.7.1412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stutman O., Yunis E. J., Good R. A. Deficient immunologic functions of NZB mice. Proc Soc Exp Biol Med. 1968 Apr;127(4):1204–1207. doi: 10.3181/00379727-127-32910. [DOI] [PubMed] [Google Scholar]
  14. Walford R. L., Hildemann W. H. Life span and lymphoma-incidence of mice injected at birth with spleen cells across a weak histocompatibility locus. Am J Pathol. 1965 Nov;47(5):713–721. [PMC free article] [PubMed] [Google Scholar]
  15. Wanebo H. J., Gallmeier W. M., Boyse E. A., Old L. J. Paraproteinemia and reticulum cell sarcoma in an inbred mouse strain. Science. 1966 Nov 18;154(3751):901–903. doi: 10.1126/science.154.3751.901. [DOI] [PubMed] [Google Scholar]

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