Abstract
A new locus is described that determines an alloantigen on the surface of lymphocytes. It differs from loci previously described in that the corresponding antibody, at least in most antisera, reacts almost exclusively with node lymphocytes, and weakly or not at all with thymuslymphocytes. Positive strains include C57BL/6, C57BL/10, C57L, C57BR/cd, and RF; negative strains include BALB/c, C3H, and SJL. The symbol Ly-4 is assigned, with the C57BL/6 allele being Ly-4b, and the BALB/c allele Ly-4a.
Keywords: antibody, node and thymus lymphocytes
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Selected References
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- AMOS D. B., ZUMPFT M., ARMSTRONG P. H-5.A AND H-6.A, TWO MOUSE ISOANTIGENS ON RED CELLS AND TISSUES DETECTED SEROLOGICALLY. Transplantation. 1963 Jul;1:270–283. doi: 10.1097/00007890-196301030-00002. [DOI] [PubMed] [Google Scholar]
- BOYSE E. A., OLD L. J., CHOUROULINKOV I. CYTOTOXIC TEST FOR DEMONSTRATION OF MOUSE ANTIBODY. Methods Med Res. 1964;10:39–47. [PubMed] [Google Scholar]
- Bailey D. W. Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation. 1971 Mar;11(3):325–327. doi: 10.1097/00007890-197103000-00013. [DOI] [PubMed] [Google Scholar]
- Boyse E. A., Itakura K., Stockert E., Iritani C. A., Miura M. Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes. Transplantation. 1971 Mar;11(3):351–353. [PubMed] [Google Scholar]
- Boyse E. A., Miyazawa M., Aoki T., Old L. J. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175–193. doi: 10.1098/rspb.1968.0032. [DOI] [PubMed] [Google Scholar]
- Cherry M., Snell G. D. A description of mu: a non-H-2 alloantigen in C3H/Sn mice. Transplantation. 1969 Oct;8(4):319–327. doi: 10.1097/00007890-196910000-00002. [DOI] [PubMed] [Google Scholar]
- FECSIK A. I., BUTLER W. T., COONS A. H. STUDIES ON ANTIBODY PRODUCTION. XI. VARIATION IN THE SECONDARY RESPONSE AS A FUNCTION OF THE LENGTH OF THE INTERVAL BETWEEN TWO ANTIGENIC STIMULI. J Exp Med. 1964 Dec 1;120:1041–1049. doi: 10.1084/jem.120.6.1041. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Graff R. J., Hildemann W. H., Snell G. D. Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci. Transplantation. 1966 Jul;4(4):425–437. [PubMed] [Google Scholar]
- Harris S., Harris T. N., Ogburn C. A. In vitro demonstration of suppressive antibody in mouse antisera vs. allogeneic spleen cells. J Immunol. 1967 Aug;99(2):447–453. [PubMed] [Google Scholar]
- Hoffman H., McDougall Some biological properties of proteins of the mouse submaxillary gland as revealed by growth of tissues on electrophoretic acrylamide gels. Exp Cell Res. 1968 Aug-Sep;51(2-3):485–503. doi: 10.1016/0014-4827(68)90138-9. [DOI] [PubMed] [Google Scholar]
- KANDUTSCH A. A., REINERT-WENCK U. Studies on a substance that promotes tumor homograft survival (the enhancing substance); its distribution and some properties. J Exp Med. 1957 Feb 1;105(2):125–139. doi: 10.1084/jem.105.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klein J., Martínková J. A new non-H-2 antigen of C57BL mice. Folia Biol (Praha) 1968;14(3):237–238. [PubMed] [Google Scholar]
- Kongshavn P. A., Bliss J. Q. Effect of mouse submandibular gland extracts on survival of H-2 incompatible skin allografts. Immunology. 1970 Aug;19(2):363–367. [PMC free article] [PubMed] [Google Scholar]
- Kongshavn P. A., Lapp W. S. Immunosuppressive effect of male mouse submandibular gland extracts on plaque-forming cells in mice: abolition by orchiectomy. Immunology. 1972 Feb;22(2):227–230. [PMC free article] [PubMed] [Google Scholar]
- MCKHANN C. F., BERRIAN J. H. Antigenic activity of various tissues in transplantation immunity. J Immunol. 1961 Mar;86:345–353. [PubMed] [Google Scholar]
- Naughton M. A., Koch J., Hoffman H., Bender V., Hagopian H. Isolation and activity of a thymocyte-trasforming factor from the mouse submaxillary gland. Exp Cell Res. 1969 Sep;57(1):95–103. doi: 10.1016/0014-4827(69)90371-1. [DOI] [PubMed] [Google Scholar]
- Nemec M., Nouza K. Some questions of non-H-2 transplantation tolerance in mice. Folia Biol (Praha) 1971;17(2):86–96. [PubMed] [Google Scholar]
- PORTER R. J. TEMPORAL STUDIES ON SUPPRESSION BY X-RAY OF ADAPTATION FOR THE SECONDARY ANTIBODY RESPONSE. J Immunol. 1964 Mar;92:425–430. [PubMed] [Google Scholar]
- Popp D. M. Histocompatibility-14: correlation of the isoantigen RHO and R-Z locus. Transplantation. 1969 Apr;7(4):233–241. doi: 10.1097/00007890-196904000-00001. [DOI] [PubMed] [Google Scholar]
- Reif A. E., Allen J. M. Mouse thymic iso-antigens. Nature. 1966 Jan 29;209(5022):521–523. doi: 10.1038/209521b0. [DOI] [PubMed] [Google Scholar]
- SNELL G. D. A cytosieve permitting sterile preparation of suspensions of tumor cells for transplantation. J Natl Cancer Inst. 1953 Jun;13(6):1511–1515. [PubMed] [Google Scholar]
- Sanderson A. R. Quantitative titration, kinetic behaviour, and inhibition of cytotoxic mouse isoantisera. Immunology. 1965 Sep;9(3):287–300. [PMC free article] [PubMed] [Google Scholar]
- Snell G. D., Démant P., Cherry M. Hemagglutination and cytotoxic studies of H-2. I. H-2.1 and related specificities in the EK crossover regions. Transplantation. 1971 Mar;11(3):210–237. doi: 10.1097/00007890-197103000-00002. [DOI] [PubMed] [Google Scholar]
- Snell G. D., Hoecker G., Stimpfling J. H. Evidence that the "R" and "Z" blood group specificities of mice are allelic and distinct from H-2. Transplantation. 1967 May;5(3):481–491. doi: 10.1097/00007890-196705000-00010. [DOI] [PubMed] [Google Scholar]
- Stimpfling J. H., Snell G. D. Detection of a non-H-2 blood group system with the aid of B10.129(5M) mice. Transplantation. 1968 May;6(3):468–475. doi: 10.1097/00007890-196805000-00018. [DOI] [PubMed] [Google Scholar]
- Takahashi T., Old L. J., Boyse E. A. Surface alloantigens of plasma cells. J Exp Med. 1970 Jun 1;131(6):1325–1341. doi: 10.1084/jem.131.6.1325. [DOI] [PMC free article] [PubMed] [Google Scholar]
