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. 1973 Apr;70(4):1156–1160. doi: 10.1073/pnas.70.4.1156

Adaptive Linkage Disequilibrium Between Two Esterase Loci of a Salamander

T Preston Webster 1
PMCID: PMC433447  PMID: 4515614

Abstract

In some populations of the salamander Plethodon cinereus, two polymorphic esterase loci are in linkage disequilibrium. Short-term stability of the linkage disequilibrium is demonstrated by an age class analysis. Long, perhaps very long, term stability is suggested by its distribution. This stability and concordant geographic variation in allelic frequencies imply selective origin and maintenance. Data on the frequencies of two color morphs suggest that formation of the linkage disequilibrium is dependent on the genetic background.

Keywords: natural selection, gametic phase unbalance, epistasis, coadaptation

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Selected References

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