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. 1973 Apr;70(4):1214–1217. doi: 10.1073/pnas.70.4.1214

Immobilized Catecholamine and Cocaine Effects on Contractility of Cardiac Muscle

J Craig Venter 1,2, John Ross Jr 1,2, Jack E Dixon 1,2, Steven E Mayer 1,2, Nathan O Kaplan 1,2
PMCID: PMC433460  PMID: 4515619

Abstract

Isoproterenol, norepinephrine, and epinephrine covalently bound to glass beads exert a positive inotropic effect on isometrically contracting papillary muscles from cats. Immobilized isoproterenol maintains increases in force and velocity of contraction for more than 5 hr. 1 μM Cocaine potentiates the action of immobilized norepinephrine, isoproterenol, and epinephrine, but not of isoproterenol in solution. The data presented indicate that the effects of immobilized catecholamines are not due to their coming off the glass. The effects observed with cocaine and immobilized catecholamines are not altered by prior treatment of the muscle with reserpine. These results suggest that the major site of catecholamine action is on receptors located on the extended surface of myocardial cells and a post-junctional site for cocaine potentiation.

Keywords: glass beads, immobilized drugs, cat papillary muscles, cocaine potentiation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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