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. 1973 May;70(5):1303–1307. doi: 10.1073/pnas.70.5.1303

Genetic Model for the Rh Blood-Group System

Richard E Rosenfield *, Fred H Allen Jr †, Pablo Rubinstein *,†
PMCID: PMC433484  PMID: 4123071

Abstract

Inherited quantitative aspects of the Rh blood-group system and susceptibility of Rh to the effects of independently segregating suppressor genes can be accounted for with a conjugated operon model. This assumes the existence of four operator or promotor (control) genes for these functions, while closely linked structural regions determine the qualitative characteristics of Rh antigens. Observed restriction of antigenic crossreactivity to the products of adjacent genetic regions and data from blood typing of nonhuman primates both suggest that Rh complexity arose from a series of gene duplications and independent mutations.

Keywords: conjugated operons, repressors, quantitative blood typing

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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