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. 1973 May;70(5):1313–1315. doi: 10.1073/pnas.70.5.1313

Acetylation of Sickle Cell Hemoglobin by Aspirin

Irving M Klotz 1, Joseph W O Tam 1
PMCID: PMC433486  PMID: 4514302

Abstract

Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with 14C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation also occurs in vivo, administration of aspirin might ameliorate the severity of sickle cell disease.

Keywords: acetylsalicylic acid, oxygenation, anemia, urea, ethanol

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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