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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1973 May;70(5):1401–1405. doi: 10.1073/pnas.70.5.1401

The Reaction of N-Iodosuccinimide with the Goitrogens: A Model for the Active Iodine of the Thyroid Gland

Ludek Jirousek 1, Morris Soodak 1
PMCID: PMC433506  PMID: 4514310

Abstract

The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve as an interesting model for the “active iodine” of the thyroid.

Keywords: dimethylsulfoxide; visible spectra; sulfur-, nitrogen-, and oxygen-containing goitrogens

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER N. M. Iodide peroxidase in rat thyroid and salivary glands and its inhibition by antithyroid compounds. J Biol Chem. 1959 Jun;234(6):1530–1533. [PubMed] [Google Scholar]
  2. ARNOTT D. G., DONIACH I. The effect of compounds allied to resorcinol upon the uptake of radioactive iodine (131I) by the thyroid of the rat. Biochem J. 1952 Feb;50(4):473–479. doi: 10.1042/bj0500473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. INGBAR S. H. The action of 1,1,3-tricyano-2-amino-1-propene (U-9189) on the thyroid gland of the rat and its effects in human thyrotoxicosis. J Clin Endocrinol Metab. 1961 Feb;21:128–139. doi: 10.1210/jcem-21-2-128. [DOI] [PubMed] [Google Scholar]
  4. Junek H., Kirk K. L., Cohen L. A. The oxidative cleavage of tyrosyl-peptide bonds during iodination. Biochemistry. 1969 May;8(5):1844–1848. doi: 10.1021/bi00833a010. [DOI] [PubMed] [Google Scholar]
  5. MALOOF F., SOODAK M. Thioacetamide, an anti-thyroid compound. Endocrinology. 1961 Jan;68:125–129. doi: 10.1210/endo-68-1-125. [DOI] [PubMed] [Google Scholar]
  6. Taurog A. Thyroid peroxidase and thyroxine biosynthesis. Recent Prog Horm Res. 1970;26:189–247. doi: 10.1016/b978-0-12-571126-5.50009-1. [DOI] [PubMed] [Google Scholar]

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