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. 1973 May;70(5):1456–1460. doi: 10.1073/pnas.70.5.1456

Conformational Analysis of Thyrotropin Releasing Factor

Antony W Burgess 1, Frank A Momany 1, Harold A Scheraga 1
PMCID: PMC433518  PMID: 4197091

Abstract

Conformational energy calculations on thyrotropin releasing factor and on several of its analogues indicate that the central histidyl residue of the native molecule is in an extended conformation. Some derivatives (with a reduced biological activity) have an altered conformation. Since some substitutions leave the conformation unchanged but alter the biological activity, these substitutions must involve the sites responsible for binding of the hormone to its receptor.

Keywords: theoretical, calculations, receptor binding, hypothalamic hormone, analogues

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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