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. 1973 May;70(5):1598–1602. doi: 10.1073/pnas.70.5.1598

Antigenic Properties of Endogenous Type-C Viruses from Spontaneously Transformed Clones of BALB/3T3

Tadao Aoki 1, George J Todaro 1
PMCID: PMC433550  PMID: 4351184

Abstract

During long-term tissue culture of spontaneously transformed clones from BALB/c 3T3 mouse-embryo cells, some clones spontaneously begin to produce high titers of endogenous murine type-C viruses. The antigenic properties of these viruses have been analyzed by indirect immunoelectronmicroscopy and can be classified into two distinguishable populations: (a) BALB/c murine myeloma-associated extracellular viruses that carry a specific envelope antigen, xVEA, different from the typical murine leukemia viral envelope antigens; and (b) previously uncharacterized type-C viruses that have neither xVEA nor the murine leukemia viral envelope antigens. The former produces PC1 antigen and the latter might induce a new cell-surface antigen. Neither of these two populations of BALB/3T3 endogenous type-C viruses was able to infect BALB/c cells but both could infect NIH Swiss cells. A single BALB/3T3 clone, then, can release infectious endogenous type-C viruses with at least two different antigenic properties. We conclude that BALB/c somatic cells contain preexisting genetic information for production of at least closely related but, nevertheless, distinct type-C viruses.

Keywords: immunoelectronmicroscopy, cell-surface antigens

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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