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. 1973 Jul;70(7):1976–1980. doi: 10.1073/pnas.70.7.1976

Further Evidence for Oncornaviruses in Human Milk: The Production of Cores

Stuart P Feldman 1,2, J Schlom 1,2,*, S Spiegelman 1,2
PMCID: PMC433646  PMID: 4124682

Abstract

Cores, or nucleoids, have been isolated from particles in human milk. The cores have a density of 1.26-1.27 g/ml and contain a 60-70S RNA in association with an RNA-instructed DNA polymerase. The data offer further evidence of similarity between human milk particles and animal RNA tumor viruses. In addition, core isolation provides a new method for detection of these particles by minimizing the difficulties generated by the presence of cell-associated debris often found in the density region (1.16-1.19 g/ml) characteristic of the intact virion. The procedures described now make available preparations of purified subviral components of a putative human RNA tumor virus.

Keywords: RNA-instructed DNA polymerase, 60-70S RNA

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1976

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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