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. 1973 Aug;70(8):2211–2214. doi: 10.1073/pnas.70.8.2211

Enzymes of the γ-Glutamyl Cycle in the Ciliary Body and Lens

Leonard L Ross 1,2, Lee Barber 1,2, Suresh S Tate 1,2, Alton Meister 1,2
PMCID: PMC433703  PMID: 4152058

Abstract

The enzymes of the γ-glutamyl cycle have been found in rabbit ciliary body and, except for 5-oxoprolinase, also in the ocular lens. Histochemical studies show that γ-glutamyl transpeptidase is localized mainly in the basal portions of the epithelial cells of the ciliary body; the findings are similar to those observed in the chloroid plexuses. The histochemical staining reaction in the ciliary epithelium is more intense than in the chloroid plexus, intestine, and kidney. γ-Glutamyl transpeptidase staining activity in the epithelium of the intestinal and renal proximal convoluted tubules is confined to the microvillus border. Moderate transpeptidase activity was found in the cytoplasm of nonpigmented epithelial cells of the iris at the posterior pupillary margin. The histochemical and enzyme activity studies are consistent with the thesis that the γ-glutamyl cycle functions in transport of amino acids across the blood-aqueous humor barrier.

Keywords: eye, rabbit, aminoacid transport, glutathione, ciliary epithelium

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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