Abstract
Human (HeLa, Chang liver, L-132, and Intestine 407) and other mammalian (XC, SV3T3, and chick-embryo) cells in tissue culture are at least as sensitive to inhibition by lipophilic acids and nitrite as bacteria. Some of these compounds are the most frequently used antimicrobial food additives. Short-chain fatty acids (up to hexanoate) and parabens induce, at partially inhibitory concentrations, a jagged cell shape in continuous epithelial-like cell lines, such as HeLa, Chang liver, L-132, and Intestine 407. This morphological effect is not mediated or enhanced by butyryl cyclic AMP, which specifically affects fibroblasts.
Keywords: food additives, short-chain fatty acids
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Freese E., Sheu C. W., Galliers E. Function of lipophilic acids as antimicrobial food additives. Nature. 1973 Feb 2;241(5388):321–325. doi: 10.1038/241321a0. [DOI] [PubMed] [Google Scholar]
- Hsie A. W., Puck T. T. Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone. Proc Natl Acad Sci U S A. 1971 Feb;68(2):358–361. doi: 10.1073/pnas.68.2.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson G. S., Friedman R. M., Pastan I. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. Proc Natl Acad Sci U S A. 1971 Feb;68(2):425–429. doi: 10.1073/pnas.68.2.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sheppard J. R. Restoration of contact-inhibited growth to transformed cells by dibutyryl adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A. 1971 Jun;68(6):1316–1320. doi: 10.1073/pnas.68.6.1316. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sheu C. W., Freese E. Effects of fatty acids on growth and envelope proteins of Bacillus subtilis. J Bacteriol. 1972 Aug;111(2):516–524. doi: 10.1128/jb.111.2.516-524.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sheu C. W., Konings W. N., Freese E. Effects of acetate and other short-chain fatty acids on sugar and amino acid uptake of Bacillus subtilis. J Bacteriol. 1972 Aug;111(2):525–530. doi: 10.1128/jb.111.2.525-530.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sreevalsan T. Association of viral ribonucleic acid with cellular membranes in chick embryo cells infected with Sindbis virus. J Virol. 1970 Oct;6(4):438–444. doi: 10.1128/jvi.6.4.438-444.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]