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. 1994 Mar 29;91(7):2415–2419. doi: 10.1073/pnas.91.7.2415

Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans.

L H Miller 1
PMCID: PMC43381  PMID: 8146132

Abstract

The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention.

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Selected References

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