TABLE 3.
Classification of Neurodevelopmental Outcomes at 18–22 mo and 6–7 y Among Survivors of HIE
| All Participants | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Classification of MDI at 18–22 mo, n | Total Population, n Classification of IQ at 6–7 y | Survivors Free of CP at 6–7 y, n Classification of IQ at 6–7 y | Survivors With CP at 6–7 y, n Classification of IQ at 6–7 y | |||||||||
| >84 | [70, 84] | <70 | Total, n (%) | >84 | [70, 84] | <70 | Total, n (%) | >84 | [70, 84] | <70 | Total, n (%) | |
| All Participants | ||||||||||||
| >84 | 39 | 12 | 2 | 53 (48) | 38 | 12 | 2 | 52 (60) | 1a | 0 | 0 | 1 (4) |
| 70–84 | 12 | 13 | 2 | 27 (25) | 12 | 13 | 2 | 27 (31) | 0 | 0 | 0 | 0 (0) |
| <70 | 1 | 2 | 27 | 30 (27) | 1 | 2 | 4 | 7 (8) | 0 | 0 | 22b,c | 22 (96) |
| Total, n (%) | 52 (47) | 27 (25) | 31 (28) | 110b (100) | 51 (59) | 27 (31) | 8 (9) | 86 (100) | 1 (4) | 0 (0) | 22b (96) | 23 (100) |
| Change from MDI at 18–22 mo to IQ at 6–7 y | Categorical (>84, [70, 84], <70) | Numeric Values | Mean Numeric Change (SD) | |||||||||
| Unchanged | 79 | 3 | 0 | |||||||||
| Deteriorated | 16 | 64 | −10.2 (7.2) | |||||||||
| Improved | 15 | 43 | 12.0 (8.9) | |||||||||
| Hypothermia Participants | ||||||||||||
| >84 | 22 | 9 | 2 | 33 (52) | 22 | 9 | 2 | 33 (62) | 0 | 0 | 0 | 0 (0) |
| 70–84 | 8 | 7 | 2 | 17 (27) | 8 | 7 | 2 | 17 (32) | 0 | 0 | 0 | 0 (0) |
| <70 | 0 | 1 | 12 | 13 (21) | 0 | 1 | 2 | 3 (6) | 0 | 0 | 9b | 9 (100) |
| Total, n (%) | 30 (48) | 17 (27) | 16 (25) | 63b (100) | 30 (57) | 17 (32) | 6d (11) | 53 (100) | 0 (0) | 0 (0) | 9b (100) | 9 (100) |
| Normothermia Participants | ||||||||||||
| >84 | 17 | 3 | 0 | 20 (43) | 16 | 3 | 0 | 19 (58) | 1a | 0 | 0 | 1 (7) |
| 70–84 | 4 | 6 | 0 | 10 (21) | 4 | 6 | 0 | 10 (30) | 0 | 0 | 0 | 0 (0) |
| <70 | 1 | 1 | 15 | 17 (36) | 1 | 1 | 2 | 4 (12) | 0 | 0 | 13 | 13 (93) |
| Total, n (%) | 22 (47) | 10 (21) | 15 (32) | 47 (100) | 21 (64) | 10 (30) | 2 (6) | 33 (100) | 1 (7) | 0 (0) | 13 (93) | 14 (100) |
Percentages do not necessarily add up to 100% because of rounding.
Child with hemiplegia.
One child treated with hypothermia is missing CP status at 6–7 y. The child had CP at the 18-mo follow-up visit and was categorized as having the primary outcome based on severe developmental delay, blindness, and epilepsy.
Among children with IQ <70 with CP (N = 22), cranial MRI lesions included 16 with basal ganglia, thalamic, internal capsule, and cerebral lesions (NRN score 2B), 1 with basal ganglia, thalamic, and internal capsule lesions only (NRN score 2A), and 1 with hemispheric devastation (NRN score 3); 4 did not have an MRI.38
Of the 6 children treated with hypothermia who had IQ <70 but no CP, 4 had cranial MRI before NICU discharge. Two had normal scans, 1 had cerebral lesions only (NRN score 1B), and 1 had basal ganglia, thalamic, internal capsule, and cerebral lesions (NRN score 2B).