Abstract
It is shown for a continuous haploid model that the common standard assumptions used in calculating the cost of gene substitution, namely, large constant population size and small constant selective value, are unnecessary. Population size may fluctuate during the course of substitution without affecting the calculated total cost. The selective intensity does not need to be small and constant to give the standard result for substitution cost. Diploid models with multiple alleles are analyzed and contrasted with standard two-allele models in respect to calculation of substitution cost. The influence of population structure on the probability of occurrence of complete gene substitution is discussed on the basis of a numerical example. The robust nature of the cost-of-selection concept is examined in the light of a conservation principle.
Keywords: gene substitution, substitutional load
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Grant V., Flake R. H. Population structure in relation to cost of selection. Proc Natl Acad Sci U S A. 1974 May;71(5):1670–1671. doi: 10.1073/pnas.71.5.1670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nei M. Fertility excess necessary for gene substitution in regulated populations. Genetics. 1971 May;68(1):169–184. doi: 10.1093/genetics/68.1.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wright S. Evolution in Mendelian Populations. Genetics. 1931 Mar;16(2):97–159. doi: 10.1093/genetics/16.2.97. [DOI] [PMC free article] [PubMed] [Google Scholar]