Fig. 3.

Spinal cord T cell infiltration is reduced in CPN^−/− mice during EAE. Leukocytes isolated from spinal cords of control (n=6) and CPN^−/− mice (n=6) as described in Materials and Methods were immunostained for CD4 and CD8 at day 15 post-induction. The infiltration of both T cell subsets at day 15 after disease induction was markedly reduced in CPN^−/− mice compared to controls. The results shown are from two experiments using cells pooled within each group of mice.