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. 1974 Nov;71(11):4500–4502. doi: 10.1073/pnas.71.11.4500

Similar Idiotypes in Antibody-Forming Cells and in Cells Synthesizing Immunoglobulins Without Detectable Antibody Function

P -A Cazenave *, T Ternynck , S Avrameas
PMCID: PMC433914  PMID: 4140504

Abstract

The occurrence of immunoglobulins with and without antibody specificity and with and without idiotypic specificity was studied, by use of enzyme-labeled antigen and antibodies, in lymph node cells of rabbits immunized with horse-radish peroxidase and hen ovalbumin. Some cells, containing immunoglobulins without detectable antibody function, were shown to contain idiotypes similar to those found in antibody-producing cells.

Keywords: rabbit, ovalbumin, peroxidase, immunoadsorption, immunoenzyme techniques

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Selected References

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