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. 2015 Jan 7;138(3):664–678. doi: 10.1093/brain/awu381

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© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Connectivity in patients with Parkinson’s disease in the OFF state. (A) Differences in endogenous connectivity between healthy controls (HC) and patients with Parkinson’s disease OFF medication (PD-OFF). Red arrows indicate a significantly reduced connectivity between two regions in patients as compared to controls. *P < 0.05, **P < 0.01, ***P < 0.001, Bonferroni-corrected for multiple comparisons. Bars represent coupling strength in 1/s. Error bars = SEM. (B) Selective difference in condition-specific connectivity between patients with Parkinson’s disease OFF medication (PD-OFF) and healthy controls (HC), depending on externally cued (Extern) or internally selected (Intern) movement lateralization. Green arrow indicates a significantly increased connectivity of the lateral premotor loop between PFC and PMC in patients OFF medication in the Extern condition. *P < 0.05, Bonferroni-corrected for multiple comparisons; n.s. = not significant. Bars represent coupling strength in 1/s. Error bars = SEM. (C) Selective difference in behavioural performance between patients with Parkinson’s disease OFF medication (PD-OFF) and healthy controls (HC), depending on externally cued (Extern, preserved performance in patients) or internally selected (Intern, impaired performance in patients) movement lateralization. *P < 0.05; n.s. = not significant. Bars represent reaction time in milliseconds (ms). Error bars = SEM. CB = cerebellum; Put = putamen; Tha = thalamus.