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. 1974 Dec;71(12):5078–5082. doi: 10.1073/pnas.71.12.5078

A New Antitumoral Agent: 9-Hydroxyellipticine. Possibility of a Rational Design of Anticancerous Drugs in the Series of DNA Intercalating Drugs

Jean-Bernard Le Pecq *, Nguyen-Dat-Xuong †, Charles Gosse *, Claude Paoletti *
PMCID: PMC434043  PMID: 4531039

Abstract

The designing of DNA intercalating drugs with high DNA affinity in the series of ellipticine has led to a new antitumoral agent, 9-hydroxyellipticine, which has a high DNA affinity, a high activity on L 1210 mice leukemia, and a lack of toxicity at therapeutic dose. The possible correlations among chemical structure, DNA reactivity, and pharmacological activity of DNA intercalating drugs are discussed.

Keywords: cancer chemotherapy, ethidium bromide, DNA unwinding, pyrido (4-3b) carbazole

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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