Table 2.

Cutoffs for dose modification decisions

Cumulative number of patients at the dose	Cumulative number of DLTs for each decision
	Escalate to next tier	Stay at current tier	De-escalate and close tier
3	0	1	2+
6	0	1	2+
9	0	1-2	3+
12	0-1	2	3+
15	0-1	2-3	4+
18	n/a	n/a	4+