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. 1974 Oct;71(10):3814–3818. doi: 10.1073/pnas.71.10.3814

The Effects of Streptomycin or Dihydrostreptomycin Binding to 16S RNA or to 30S Ribosomal Subunits

Robert T Garvin 1, Debajit K Biswas 1,*, Luigi Gorini 1
PMCID: PMC434274  PMID: 4139702

Abstract

Evidence is presented suggesting that streptomycin binds to 16S RNA or to 30S ribosomal subunits at the same topographical site located on the RNA chain. The equally bactericidal dihydrostreptomycin binds to the same site as streptomycin but with lower affinity. The effect of drug binding to 16S RNA (measured by reconstitution inhibition) is readily reversible, while that of drug binding to 30S subunits (measured by misreading) persists after removal of the drug. Binding of the drug is not a necessary and sufficient reason for killing.

Keywords: misreading and drug binding, 30S subunit reconstitution and drug binding

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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