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. 1974 Oct;71(10):4229–4231. doi: 10.1073/pnas.71.10.4229

Cholesterol as a Bioregulator in the Development and Inhibition of Leukemia

M Inbar 1, M Shinitzky 1
PMCID: PMC434364  PMID: 4530299

Abstract

Leukemia in mice and humans is accompanied by a marked deficiency of unesterified cholesterol in the surface membrane of leukemic cells as compared to normal leukocytes. This deficiency induces a significant reduction in their membrane microviscosity. Since cholesterol in the cell surface membrane is exchangeable with cholesterol in the serum lipoproteins, concomitant to the cellular deficiency of cholesterol, the average level of cholesterol in the blood serum of leukemic patients is substantially below the average normal level. Based on these observations and the effect of membrane microviscosity on biological functions, a working hypothesis that describes the role of cholesterol in the development and inhibition of leukemia is suggested. This hypothesis can also account for the effect of cholesterol and membrane microviscosity on various other cellular activities of leukocytes.

Keywords: malignant transformation, membrane microviscosity, lipid layers, normal leukocytes, leukemic cells, blood serum

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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