Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1974 Oct;71(10):4264–4266. doi: 10.1073/pnas.71.10.4264

Enhancement of Tumor Growth by Graft-versus-host Reaction

S Okubo *,‡, H F Oettgen *, S S Caiazza †, Z Ovary †
PMCID: PMC434372  PMID: 4154441

Abstract

A graft-versus-host reaction was induced in (BALB/c × C5 7BL/6)F1 mice by intravenous injection of BALB/c spleen cells. Six days later, the mice received subcutaneous grafts of a chemically induced BALB/c sarcoma. The growth of the tumor grafts was accelerated.

Keywords: cancer, mice

Full text

PDF
4264

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAESE R. M., MARTINEZ C., GOOD R. A. IMMUNOLOGIC INCOMPETENCE OF IMMUNOLOGICALLY RUNTED ANIMALS. J Exp Med. 1964 Feb 1;119:211–224. doi: 10.1084/jem.119.2.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Borberg H., Oettgen H. F., Choudry K., Beattie E. J., Jr Inhibition of established transplants of chemically induced sarcomas in syngeneic mice by lymphocytes from immunized donors. Int J Cancer. 1972 Nov;10(3):539–547. doi: 10.1002/ijc.2910100312. [DOI] [PubMed] [Google Scholar]
  3. Crowle A. J., Hu C. C. Adoptive transfer of immunologic tolerance into normal mice. J Immunol. 1969 Dec;103(6):1242–1247. [PubMed] [Google Scholar]
  4. DELORME E. J., ALEXANDER P. TREATMENT OF PRIMARY FIBROSARCOMA IN THE RAT WITH IMMUNE LYMPHOCYTES. Lancet. 1964 Jul 18;2(7351):117–120. doi: 10.1016/s0140-6736(64)90126-6. [DOI] [PubMed] [Google Scholar]
  5. Ellman L., Katz D. H., Green I., Paul W. E., Benacerraf B. Mechanisms involved in the antileukemic effect of immunocompetent allogeneic lymphoid cell transfer. Cancer Res. 1972 Jan;32(1):141–148. [PubMed] [Google Scholar]
  6. Gershon R. K., Kondo K. Infectious immunological tolerance. Immunology. 1971 Dec;21(6):903–914. [PMC free article] [PubMed] [Google Scholar]
  7. KALISS N. Immunological enhancement of tumor homografts in mice: a review. Cancer Res. 1958 Oct;18(9):992–1003. [PubMed] [Google Scholar]
  8. Katz D. H., Ellman L., Paul W. E., Green I., Benacerraf B. Resistance of guinea pigs to leukemia following transfer of immunocompetent allogeneic lymphoid cells. Cancer Res. 1972 Jan;32(1):133–140. [PubMed] [Google Scholar]
  9. Katz D. H., Paul W. E., Goidl E. A., Benacerraf B. Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med. 1971 Feb 1;133(2):169–186. doi: 10.1084/jem.133.2.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lapp W. S., Möller G. Prolonged survival of H-2 incompatible skin allografts on F1 animals treated with parental lymphoid cells. Immunology. 1969 Sep;17(3):339–344. [PMC free article] [PubMed] [Google Scholar]
  11. Nadler S. H., Moore G. E. Immunotherapy of malignant melanoma. Geriatrics. 1968 May;23(5):150–153. [PubMed] [Google Scholar]
  12. Okumura K., Tada T. Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response. J Immunol. 1971 Dec;107(6):1682–1689. [PubMed] [Google Scholar]
  13. Old L. J., Stockert E., Boyse E. A., Geering G. A study of passive immunization against a transplanted G+ leukemia with specific antiserum. Proc Soc Exp Biol Med. 1967 Jan;124(1):63–68. doi: 10.3181/00379727-124-31667. [DOI] [PubMed] [Google Scholar]
  14. Osborne D. P., Jr, Katz D. H. The allogeneic effect in inbred mice. I. Experimental conditions for the enhancement of hapten-specific secondary antibody responses by the graft-versus-host reaction. J Exp Med. 1972 Sep 1;136(3):439–454. doi: 10.1084/jem.136.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES