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. 1980 Apr;65(4):926–930. doi: 10.1172/JCI109747

Origin of platelet-derived growth factor in megakaryocytes in guinea pigs.

A Chernoff, R F Levine, D S Goodman
PMCID: PMC434482  PMID: 7358851

Abstract

Growth factor activity, as determined by the stimulation of [3H]thymidine incorporation into the DNA of quiescent 3T3 cells in culture, was found in lysates of guinea pig platelets and megakaryocytes. Quantitative dilution studies demonstrated that, of the cells present in the guinea pig bone marrow, only the megakaryocyte possessed quantitatively significant growth factor activity. The amount of activity present in one megakaryocyte was equivalent to that present in 1,000-5,000 platelets, a value approximately comparable to the number of platelets shed from a single megakaryocyte. It is suggested that guinea pig platelet-derived growth factor has its origin in the megakaryocyte.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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