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. Author manuscript; available in PMC: 2016 Feb 27.
Published in final edited form as: Circ Res. 2015 Jan 20;116(5):e28–e39. doi: 10.1161/CIRCRESAHA.116.304682

Figure 2.

Figure 2

CaMKIIδ knockout prevents Gq-induced cardiac dysfunction. A, B, Echocardiographic indices of left ventricular (LV) function and LV dilatation. Shown are fractional shortening (A), LV Internal Systolic Diameter (LVIDs, B); (N=7 for WT, N=5 for KO, N=9 for Gq and N=8 for Gq/KO). C, Indices of cardiac contractility and relaxation. Shown are maximal rates of LV-pressure increase (dP/dtmax) and decrease (dP/dtmin), N= 4 per group. D, Lung weight/Body Weight ratio, an indicator of the severity of functional decompensation (N= 6–10 per group). All values are expressed as mean ± SEM. #, p < 0.05 versus WT, *; p < 0.05 versus Gq. WT, wildtype; KO, CaMKIIδ-knockout; Gq, Gq-transgenic; Gq/KO, Gq-transgenic in a CaMKIIδ-knockout background.