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Rab6 depletion inhibits HSV1 capsid envelopment. Hela cells transfected with (A) neg, (B) Rab1 or (C) Rab6 siRNAs were infected 2 days later with HSV1, fixed at 16 h and processed for transmission electron microscopy. ER, endoplasmic reticulum; GA, Golgi apparatus; Ca, capsid. Arrowheads indicate naked capsids. Thick arrows indicate capsids associated with wrapping membranes. Thin arrows indicate continuum with the cytoplasm. Scale bar = 500 nm.
