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. 1994 Mar 29;91(7):2853–2857. doi: 10.1073/pnas.91.7.2853

Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms.

R H Farkas 1, S Nakajima 1, Y Nakajima 1
PMCID: PMC43469  PMID: 8146199

Abstract

The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.

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Selected References

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