Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Apr 12;91(8):3019–3023. doi: 10.1073/pnas.91.8.3019

Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers.

N E Cockett 1, S P Jackson 1, T L Shay 1, D Nielsen 1, S S Moore 1, M R Steele 1, W Barendse 1, R D Green 1, M Georges 1
PMCID: PMC43506  PMID: 8159698

Abstract

A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries). Preliminary results indicate that an autosomal dominant gene may be responsible for this economically advantageous trait. We have exploited the conservation in sequence and chromosomal location of DNA markers across Bovidae to map the corresponding callipyge locus to ovine chromosome 18 using a battery of bovine chromosome 21 markers. Chromosomal localization of the ovine callipyge locus is the first step toward positional cloning of the corresponding gene.

Full text

PDF
3019

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barendse W., Armitage S. M., Kirkpatrick B. W., Moore S. S., Georges M., Womack J. E., Hetzel J. A genetic map of index DNA loci on bovine chromosome 21. Genomics. 1993 Dec;18(3):598–601. doi: 10.1016/s0888-7543(05)80361-1. [DOI] [PubMed] [Google Scholar]
  2. Beckmann J. S., Richard I., Hillaire D., Broux O., Antignac C., Bois E., Cann H., Cottingham R. W., Jr, Feingold N., Feingold J. A gene for limb-girdle muscular dystrophy maps to chromosome 15 by linkage. C R Acad Sci III. 1991;312(4):141–148. [PubMed] [Google Scholar]
  3. Chowdhary B. P., Harbitz I., Davies W., Gustavsson I. Localization of the calcium release channel gene in cattle and horse by in situ hybridization: evidence of a conserved synteny with glucose phosphate isomerase. Anim Genet. 1992;23(1):43–50. [PubMed] [Google Scholar]
  4. Georges M., Dietz A. B., Mishra A., Nielsen D., Sargeant L. S., Sorensen A., Steele M. R., Zhao X., Leipold H., Womack J. E. Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated quantitative trait locus. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1058–1062. doi: 10.1073/pnas.90.3.1058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Georges M., Drinkwater R., King T., Mishra A., Moore S. S., Nielsen D., Sargeant L. S., Sorensen A., Steele M. R., Zhao X. Microsatellite mapping of a gene affecting horn development in Bos taurus. Nat Genet. 1993 Jun;4(2):206–210. doi: 10.1038/ng0693-206. [DOI] [PubMed] [Google Scholar]
  6. Georges M., Gunawardana A., Threadgill D. W., Lathrop M., Olsaker I., Mishra A., Sargeant L. L., Schoeberlein A., Steele M. R., Terry C. Characterization of a set of variable number of tandem repeat markers conserved in bovidae. Genomics. 1991 Sep;11(1):24–32. doi: 10.1016/0888-7543(91)90098-y. [DOI] [PubMed] [Google Scholar]
  7. Georges M., Lathrop M., Hilbert P., Marcotte A., Schwers A., Swillens S., Vassart G., Hanset R. On the use of DNA fingerprints for linkage studies in cattle. Genomics. 1990 Mar;6(3):461–474. doi: 10.1016/0888-7543(90)90476-b. [DOI] [PubMed] [Google Scholar]
  8. Jeffreys A. J., Neumann R., Wilson V. Repeat unit sequence variation in minisatellites: a novel source of DNA polymorphism for studying variation and mutation by single molecule analysis. Cell. 1990 Feb 9;60(3):473–485. doi: 10.1016/0092-8674(90)90598-9. [DOI] [PubMed] [Google Scholar]
  9. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lee B., Godfrey M., Vitale E., Hori H., Mattei M. G., Sarfarazi M., Tsipouras P., Ramirez F., Hollister D. W. Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature. 1991 Jul 25;352(6333):330–334. doi: 10.1038/352330a0. [DOI] [PubMed] [Google Scholar]
  11. Libert F., Lefort A., Okimoto R., Womack J., Georges M. Construction of a bovine genomic library of large yeast artificial chromosome clones. Genomics. 1993 Nov;18(2):270–276. doi: 10.1006/geno.1993.1465. [DOI] [PubMed] [Google Scholar]
  12. MacLennan D. H., Phillips M. S. Malignant hyperthermia. Science. 1992 May 8;256(5058):789–794. doi: 10.1126/science.1589759. [DOI] [PubMed] [Google Scholar]
  13. Moore S. S., Sargeant L. L., King T. J., Mattick J. S., Georges M., Hetzel D. J. The conservation of dinucleotide microsatellites among mammalian genomes allows the use of heterologous PCR primer pairs in closely related species. Genomics. 1991 Jul;10(3):654–660. doi: 10.1016/0888-7543(91)90448-n. [DOI] [PubMed] [Google Scholar]
  14. O'Brien S. J., Womack J. E., Lyons L. A., Moore K. J., Jenkins N. A., Copeland N. G. Anchored reference loci for comparative genome mapping in mammals. Nat Genet. 1993 Feb;3(2):103–112. doi: 10.1038/ng0293-103. [DOI] [PubMed] [Google Scholar]
  15. Steele M. R., Georges M. Generation of bovine multisite haplotypes using random cosmid clones. Genomics. 1991 Aug;10(4):889–904. doi: 10.1016/0888-7543(91)90177-g. [DOI] [PubMed] [Google Scholar]
  16. Steffen P., Eggen A., Dietz A. B., Womack J. E., Stranzinger G., Fries R. Isolation and mapping of polymorphic microsatellites in cattle. Anim Genet. 1993 Apr;24(2):121–124. doi: 10.1111/j.1365-2052.1993.tb00252.x. [DOI] [PubMed] [Google Scholar]
  17. Sun H. S., Dentine M. R., Kirkpatrick B. W. A polymorphic microsatellite (UWCA4) detected on bovine chromosome 21. Anim Genet. 1993 Apr;24(2):149–149. doi: 10.1111/j.1365-2052.1993.tb00275.x. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES