There are errors in Tables 1, 2, and 3 of the published article. Please view the corrected tables here.
Table 1. Baseline characteristics, perceived barriers and acceptance of the HPV vaccine; comparing respondents and non-respondents of the follow-up study.
TOTAL BASELINE (n = 287) | FOLLOW-UP RESPONDENTS (n = 256) | NON-RESPONDENTS (n = 31) | ||
---|---|---|---|---|
BASELINE CHARACTERISTICS | ||||
Median (IQR) | Median (IQR) | Median (IQR) | p-value | |
Participant age at baseline | 35 (32–40) | 35 (32–40) | 35 (39–40) | 0.43 |
Range (years) | 21–59 | 21–59 | 23–56 | |
Age of daughter at baseline | 12 (11–14) | 12 (11–14) | 12 (11–13) | 0.68 |
Range (years) | 8–18 | 8–18 | 8–17 | |
Years of education of participant | 8 (7–12) | 8 (7–12) | 8 (6–11) | 0.35 |
Range (years)* | 0–13+ | 0–13+ | 0–13+ | |
Housing characteristics** | 5 (4–5) | 5 (4–5) | 5 (4–6) | 0.04 |
Range | 1–7 | 2–7 | 3–7 | |
n (%) | n (%) | n (%) | p-value | |
Marital status of participant | 0.85 | |||
With partner | 217 (75.6) | 194 (75.8) | 23 (74.2) | |
Without partner | 70 (24.4) | 62 (24.2) | 8 (25.8) | |
Religious affiliation of participant | 0.48 | |||
Protestant | 226 (79.3) | 204 (80.3) | 22 (71.0) | |
Catholic | 46 (16.1) | 39 (15.3) | 7 (22.6) | |
Muslim | 13 (4.6) | 11 (4.3) | 2 (6.4) | |
Origin of participant*** | 0.98 | |||
urban | 171 (60.2) | 153 (60.2) | 18 (60.0) | |
rural—outside Kenya | 113 (39.8) | 101 (39.8) | 12 (40.0) | |
Ever heard of cervical cancer? | 0.37 | |||
No—don’t know | 117 (40.9) | 102 (40.0) | 15 (48.4) | |
Yes | 169 (59.1) | 153 (60.0) | 16 (51.6) | |
BASELINE BARRIERS: if you would decide not to vaccinate, why would that be? | ||||
Need more information? | 0.40 | |||
(strongly) disagree | 98 (34.6) | 84 (33.3) | 14 (45.2) | |
neutral | 17 (6.0) | 15 (5.9) | 2 (6.4) | |
(strongly) agree | 168 (59.4) | 153 (60.7) | 15 (48.4) | |
Doubt the vaccine works? | 0.36 | |||
(strongly) disagree | 197 (70.1) | 174 (69.6) | 23 (74.2) | |
neutral | 24 (8.5) | 20 (8.0) | 4 (12.9) | |
(strongly) agree | 60 (21.3) | 56 (22.4) | 4 (12.9) | |
Fear of side effects? | 0.26 | |||
(strongly) disagree | 149 (52.5) | 129 (51.0) | 20 (64.5) | |
neutral | 27 (9.5) | 26 (10.3 | 1 (3.2) | |
(strongly) agree | 108 (38.0) | 98 (38.7) | 10 (32.3) | |
Fear of interference with fertility? | 0.43 | |||
(strongly) disagree | 171 (60.4) | 149 (59.1) | 22 (71.0) | |
neutral | 45 (15.9) | 41 (16.3) | 4 (12.9) | |
(strongly) agree | 67 (23.7) | 62 (24.6) | 5 (16.1) | |
Afraid of unsafe administration? | 0.07 | |||
(strongly) disagree | 203 (71.7) | 177 (70.2) | 26 (83.9) | |
neutral | 17 (6.0) | 14 (5.6) | (9.7) | |
(strongly) agree | 63 (22.3) | 61 (24.2) | 2 (6.4) | |
It might encourage unsafe sex | 0.94 | |||
(strongly) disagree | 238 (84.7) | 212 (84.8) | 26 (83.9) | |
neutral | 23 (8.2) | 20 (8.0) | 3 (9.7) | |
(strongly) agree | 20 (7.1) | 18 (7.2) | 2 (6.4) | |
Daughter is too young for vaccine against an STI? | 0.91 | |||
(strongly) disagree | 250 (88.3) | 222 (88.1) | 28 (90.3) | |
neutral | 9 (3.2) | 8 (3.2) | 1 (3.2) | |
(strongly) agree | 24 (8.5) | 22 (8.7) | 2 (6.4) | |
Partner won’t approve? | 0.70 | |||
(strongly) disagree **** | 221 (78.4) | 196 (78.1) | 25 (80.6) | |
neutral | 30 (10.6) | 28 (11.2) | 2 (6.4) | |
(strongly) agree | 31 (11.0) | 27 (10.8) | 4 (12.9) | |
Vaccination takes a lot of time | 0.75 | |||
(strongly) disagree | 275 (96.8) | 245 (96.8) | 30 (96.8) | |
neutral | 6 (2.1) | 5 (2.0) | 1 (3.2) | |
(strongly) agree | 3 (1.1) | 3 (1.2) | 0 (0.00) | |
Inconvenience of 3 doses needed | 0.08 | |||
(strongly) disagree | 265 (96.0) | 236 (96.3) | 29 (93.5) | |
neutral | 6 (2.2) | 6 (2.4) | 0 (0.0) | |
(strongly) agree | 5 (1.8) | 3 (1.2) | 2 (6.4) | |
BASELINE ACCEPTANCE | ||||
Would you vaccinate your daughter against cervical cancer? | 0.69 | |||
very unlikely | 6 (2.1) | 6 (2.3) | 0 (0.0) | |
unlikely | 3 (1.0) | 3 (1.2) | 0 (0.0) | |
neutral | 25 (8.7) | 21 (8.2) | 4 (12.9) | |
likely | 80 (27.9) | 73 (28.5) | 7 (22.6) | |
very likely | 173 (60.3) | 153 (59.8) | 20 (64.5) |
IQR = interquartile range
*13+: those who studied in higher education i.e. college (middle level) and/or university
**housing: continuous variable constructed by scoring aspects of the living place: material of the roof, walls and floors, and toilet and water facilities
*** women were asked where they had lived for most of the time up to 12 years of age
**** includes participants without a relationship
Table 2. Bivariate logistic regression with acceptance and uptake of the HPV vaccine as outcomes.
VARIABLE | BASELINE ACCEPTANCE | UPTAKE | ||||||
---|---|---|---|---|---|---|---|---|
n | Acceptance (%) | AOR | [95% CI] | n | Uptake (%) | AOR | [95% CI] | |
BASELINE CHARACTERISTICS | ||||||||
Participant age at baseline | 286 | 1.05* | [1.01–1.08] | 254 | 1.01 | [0.97–1.04] | ||
Age of daughter at baseline | 285 | 1.14 | [0.85–1.54] | 253 | 1.03 | [0.86–1.23] | ||
Years of education of participant | 279 | 0.10 | [0.88–1.23] | 247 | 1.05 | [0.99–1.11] | ||
Housing | 287 | 0.81 | [0.61–1.08] | 255 | 1.12 | [0.74–1.70] | ||
Marital status of participant | 287 | 255 | ||||||
With partner | 188/217 (86.6) | 57/193 (29.5) | ||||||
Without partner | 65/70 (92.9) | 0.53 | [0.15–1.84] | 22/62 (35.5) | 0.75 | [0.43–1.32] | ||
Religion of participant | 285 | 253 | ||||||
Protestant | 202/226 (89.4) | 58/203 (28.6) | ||||||
Catholic | 41/46 (89.1) | 1.07 | [0.23–4.88] | 17/39 (43.6) | 1.92* | [1.19–3.09] | ||
Muslim | 8/13 (61.5) | 0.20 | [0.04–1.09] | 4/11 (36.4) | 1.42 | [0.48–4.18] | ||
Origin of participant | 284 | 253 | ||||||
Urban | 155/171 (90.6) | 56/153 (36.6) | ||||||
Rural—outside Kenya | 96/113 (85.0) | 0.61 | [0.19–1.94] | 22/100 (22.0) | 0.48 | [0.21–1.10] | ||
Ever heard of cervical cancer? | 286 | 254 | ||||||
No—don’t know | 107/117 (91.4) | 24/102 (23.5) | ||||||
Yes | 145/169 (85.8) | 0.55 | [0.22–1.37] | 55/152 (36.2) | 1.93* | [1.16–3.19] | ||
BASELINE BARRIERS: if you would decide not to vaccinate, why would that be? | ||||||||
Need for more information? | 283 | 1.00 | [0.84–1.20] | 251 | 1.02 | [0.89–1.17] | ||
Doubt the vaccine works? | 281 | 0.75* | [0.59–0.97] | 249 | 0.98 | [0.76–1.26] | ||
Fear of side effect? | 284 | 0.69* | [0.52–0.91] | 252 | 1.00 | [1.76–1.31] | ||
Fear of interference with fertility? | 283 | 0.71* | [0.53–0.96] | 251 | 0.94 | [0.71–1.25] | ||
Afraid of unsafe administration (i.e. using unclean needles) | 283 | 0.76** | [0.64–0.91] | 251 | 1.04 | [0.78–1.40] | ||
It might encourage unsafe sex | 282 | 0.80 | [0.53–1.20] | 250 | 0.81 | [0.52–1.26] | ||
Daughter is too young for vaccine against an STI? | 283 | 0.54** | [0.38–0.76] | 251 | 0.94 | [0.61–1.43] | ||
Partner won’t approve?° | 282 | 0.44*** | [0.31–0.61] | 250 | 0.87 | [0.68–1.09] | ||
Vaccination takes a lot of time | 284 | 0.51 | [0.24–1.12] | 252 | 0.86 | [0.60–1.21] | ||
Inconvenience: 3 doses needed | 276 | 0.67 | [0.36–1.24] | 244 | 0.94 | [0.57–1.55] | ||
ACCEPTANCE—WELL-INFORMED | ||||||||
Would you vaccinate your daughter? (Baseline) | 255 | |||||||
neutral—(very) unlikely | 5/30 (16.7) | - | ||||||
(very) likely | 74/225 (32.9) | 2.57* | [1.11–5.94] | |||||
Were you well-informed about the cervical cancer vaccination program? (at follow-up) | 235 | |||||||
No | 10/88 (11.4) | - | ||||||
Yes | 68/147 (46.3) | 6.37** | [2.21–18.36] |
AOR: adjusted odds ratio—CI: confidence interval
° participants without a relationship are included in category ‘strongly disagree’
* p<0.05
** p<0.01
*** p<0.001
Table 3. Multivariate logistic regression with acceptance and uptake of the HPV vaccine as outcomes.
ACCEPTANCE—AOR [95% CI] | UPTAKE—AOR [95% CI] | ||||||
---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | Model 4 | |
n = 270 | n = 278 | n = 280 | n = 239 | n = 246 | n = 247 | n = 227 | |
ACCEPTANCE—WELL-INFORMED | |||||||
Would you vaccinate your daughter? (at baseline) | 3.36 | ||||||
(very) likely (ref: neutr.–(very) unlikely) | [0.80–14.1] | ||||||
Were you well-informed about the vaccination program? (at follow-up) | 6.37** | ||||||
Yes (ref: No) | [2.24–18.1] | ||||||
BASELINE CHARACTERISTICS | |||||||
Age of participant at baseline | 1.06* | 1.003 | |||||
[1.00–1.12] | nw | [0.96–1.04] | nw | ||||
Age of daughter at baseline | 1.05 | 1.088 | |||||
[0.77–1.44] | nw | [0.86–1.37] | nw | ||||
Years of education of participant | 0.98 | 1.051 | |||||
[0.89–1.08] | nw | [0.97–1.14] | nw | ||||
Housing | 0.90 | nw | 0.972 | ||||
[0.64–1.26] | [0.60–1.56] | nw | |||||
Marital status of participant | |||||||
Without partner (ref: with partner) | 0.56 | 0.689 | |||||
[0.15–2.00] | nw | [0.37–1.29] | nw | ||||
Religion of participant. (ref: protestant.) | |||||||
Catholic | 1.35 | 1.416 | |||||
[0.28–6.42] | [0.57–3.50] | ||||||
Muslim | 0.078** | 1.171 | |||||
[0.02–0.38] | nw | [0.42–3.26] | nw | ||||
Origin of participant | |||||||
rural—outside Kenya (ref: urban) | 0.49 | 0.546 | 0.48* | 0.53* | |||
[0.15–1.62] | nw | [0.21–1.42] | [0.23–0.99] | [0.29–0.97] | |||
Ever heard of cervical cancer? (at baseline) | 0.43 | 0.46 | 1.610* | 1.84* | 2.07* | ||
Yes (ref: No–don’t know) | [0.17–1.11] | [0.17–1.30] | [1.09–2.38] | [1.04–3.26] | [1.18–3.63] | ||
BARRIERS AT BASELINE | |||||||
Need for more information | 1.21 | 0.99 | |||||
[0.86–1.71] | nw | [0.83–1.18] | nw | ||||
Barriers inherent to vaccination° | 0.86 | 1.06 | |||||
[0.56–1.33] | nw | [0.68–1.63] | nw | ||||
It might encourage unsafe sex | 0.94 | 0.82 | |||||
[0.57–1.53] | nw | [0.49–1.37] | nw | ||||
Daughter is too young for vaccine against an STI? | 0.72 | 0.67* | 0.99 | ||||
[0.48–1.10] | [0.45–0.99] | [0.57–1.69] | nw | ||||
Partner won’t approve? | 0.50** | 0.47*** | 0.89 | 0.83 | 0.99 | ||
[0.33–0.74] | [0.32–0.71] | [0.68–1.16] | [0.67–1.03] | [0.74–1.32] | |||
Barriers related to time constraints°° | 0.68 | 1.00 | |||||
[0.27–1.69] | nw | [0.57–1.74] | nw | ||||
Cons | 9.86 | 103.60** | 138.38*** | 0.20 | 0.68 | 1.07 | 0.06* |
F-statistic (p) | 410.3 (0.04) | 14.15 (0.01) | 13.93 (0.00) | 2.661 (0.44) | 0.304 (0.91) | 5.916 (0.02) | 4.443 (0.06) |
Model 1: including baseline characteristics; model 2: including barriers perceived at baseline; model 3: including baseline characteristics and barriers obtained by stepwise backward regression—model 4: model 3 + acceptance and being well-informed about the HPV vaccination program
AOR: adjusted odds ratio—CI: confidence interval
°average of: doubt the vaccine works, fear of side effects and interference with fertility, and afraid of unsafe administration; alpha = 0.90
°° average of: vaccination takes a lot of time and 3 doses are inconvenient; alpha = 0.79
nw: not withheld in backward stepwise regression
* p<0.05
** p<0.01
*** p<0.00
Reference
- 1. Vermandere H, Naanyu V, Mabeya H, Vanden Broeck D, Michielsen K, Degomme O (2014) Determinants of Acceptance and Subsequent Uptake of the HPV Vaccine in a Cohort in Eldoret, Kenya. PLoS ONE 9(10): e109353 doi:10.1371/journal.pone.0109353 [DOI] [PMC free article] [PubMed] [Google Scholar]