Correction: Pea Fiber and Wheat Bran Fiber Show Distinct Metabolic Profiles in Rats as Investigated by a ¹H NMR-Based Metabolomic Approach

There are errors in the Author Contributions. The correct contributions are: Conceived and designed the experiments: GL LX TF YC GJ HZ JW XC CW. Performed the experiments: GL LX TF JW. Analyzed the data: GL LX TF. Contributed reagents/materials/analysis tools: GL. Wrote the paper: GL.

Additionally, there is an error in the legends for Fig. 1 and Fig. 2. “Table 1” should say “Table 5.” Please view the complete, correct Fig. 1 and Fig. 2 legends below.

Fig 1. Representative one-dimensional ¹H NMR spectra urine metabolites obtained from the (A) control, (B) pea fiber, and (C) wheat bran fiber groups.

The region of δ6.2–9.5 was magnified 16 times compared with corresponding region of δ0.5–6.2 for the purpose of clarity. Metabolite keys are given in Table 5.

Fig 2. Typical 600 MHz ¹H NMR spectra of plasma metabolites obtained from the (A) control, (B) pea fiber, and (C) wheat bran fiber groups.

The region of δ6.0–9.0 was magnified 24 times compared with corresponding region of δ0.5–6.0 for the purpose of clarity. Metabolite keys are given in Table 5.

Table 5. ¹H NMR data for metabolites in rat urine and plasma.

keys	Metabolites	moieties	δ 1H (ppm) and multiplicity	samples a
1	bile acids	CH3	0.62(m), 0.75(m)	U
2	Butyrate	CH3	0.9(t)	U
3	α-hydroxybutyrate	CH3	0.94(t)	U
4	α-hydroxy-iso-valerate	δCH3	0.97(d)	U
5	isobutyrate	CH3	1.14(d)	U, P
6	Ethanol	CH3, CH2	1.19(t), 3.66(q)	U, P
7	methylmalonate	CH3, CH	1.26(d), 3.76(m)	U
8	α-hydroxy-n-valerate	CH3, γCH2	0.89(t), 1.31(m)	U
9	lactate	αCH, βCH3	4.13(q), 1.33(d)	U, P
10	alanine	αCH, βCH3	3.77(q), 1.48(d)	U, P
11	citrulline	γCH2, βCH2	1.56(m), 1.82(m)	U
12	acetate	CH3	1.92(s)	U, P
13	acetamide	CH3	1.99(s)	U
14	N-acetylglutamate	βCH2, γCH2, CH3	2.07(m), 1.88(m), 2.04(s)	U
15	acetone	CH3	2.25(s)	U, P
16	acetoacetate	CH3	2.3(s)	U
17	succinate	CH2	2.41(s)	U
18	α-ketoglutarate	βCH2, γCH2	2.45(t), 3.01(t)	U
19	citrate	CH2	2.55(d), 2.68(d)	U, P
20	methylamine	CH3	2.62(s)	U
21	dimethylamine	CH3	2.73(s)	U
22	trimethylamine	CH3	2.88(s)	U
23	dimethylglycine	CH3	2.93(s)	U
24	creatine	CH3, CH2	3.04(s), 3.93(s)	U, P
25	creatinine	CH3, CH2	3.04(s), 4.05(s)	U, P
26	ethanolamine	CH2	3.13(t)	U
27	malonate	CH2	3.16(s)	U
28	choline	OCH2, NCH2, N(CH3)3	4.07(t), 3.53(t), 3.20(s)	U, P
29	taurine	-CH2-S, -CH2-NH2	3.26(t), 3.43(t)	U
30	glycine	CH2	3.57(s)	U
31	phenylacetyglycine	2,6-CH, 3,5-CH, 7-CH, 10-CH	7.31(t), 7.37(m), 7.42(m), 3.68(s)	U
32	hippurate	CH2, 3,5-CH, 4-CH, 2,6-CH	3.97(d), 7.57(t), 7.65(t), 7.84(d)	U
33	N-methylnicotinamide	CH3, 5-CH, 4-CH, 6-CH, CH2	4.44(s), 8.18(d), 8.89(d), 8.96(d), 9.26(s)	U
34	β-glucose	1-CH, 2-CH, 3-CH, 4-CH, 5-CH, 6-CH	4.65(d), 3.25(dd), 3.49(t), 3.41(dd), 3.46(m), 3.73(dd), 3.90(dd)	U, P
35	α-glucose	1-CH, 2-CH, 3-CH, 4-CH, 5-CH, 6-CH	5.24(d), 3.54(dd), 3.71(dd), 3.42(dd), 3.84(m), 3.78(m)	U, P
36	allantoin	CH	5.40(s)	U, P
37	urea	NH2	5.82(s)	U
38	homogentisate	6-CH, 5-CH	6.7(d), 6.76(d),	U
39	p-hydroxyphenylacetate	6-CH, 2-CH, 3,5-CH	3.6(s), 6.87(d), 7.15(d)	U
40	m-hydroxyphenylacetate	6-CH, 4-CH, 3-CH	6.92(m), 7.04(d), 7.26(t)	U
41	nicotinate	2,6-CH, 4-CH, 5-CH	8.62(d), 8.25(d), 7.5(dd)	U
42	4-aminohippurate	CH2	7.71(d)	U
43	trigonelline	2-CH, 4-CH, 6-CH, 5-CH, CH3	9.12(s), 8.85(m), 8.83(dd), 8.19(m), 4.44(s)	U
44	formate	CH	8.46(s)	U
45	unknown		8.54(s)	U
46	HDL*	CH3(CH2)n	0.84(m)	P
47	LDL*	CH3(CH2)n	0.87(m)	P
48	VLDL*	CH3CH2CH2C =	0.89(t)	P
49	isoleucine	αCH, βCH, βCH3, γCH2, δCH3	3.68(d), 1.99(m), 1.01(d), 1.26(m), 1.47(m), 0.94(t)	P
50	leucine	αCH, βCH2, γCH, δCH3	3.73(t), 1.72(m), 1.72(m), 0.96(d), 0.97(d)	P
51	valine	αCH, βCH, γCH3	3.62(d), 2.28(m), 0.99(d), 1.04(d)	P
52	propionate	CH3, CH2	1.08(t), 2.18(q)	P
53	3-hydroxybutyrate	αCH2, βCH, γCH3	2.28(dd), 2.42(dd), 4.16(m), 1.20(d)	P
54	lipids (triglycerids and fatty acids)	(CH2)n, CH2CH2CO, CH2C = C, CH2CO，C = CCH2C = C	1.28(m)，1.58(m), 2.01(m), 2.24(m), 2.76(m)	P
55	lysine	αCH, βCH2, γCH2, εCH2	3.76(t), 1.91(m), 1.48(m), 1.72(m), 3.01(t)	P
56	N-acetyl glycoprotein	CH3	2.04(s)	P
57	O-acetyl glycoprotein	CH3	2.08(s)	P
58	glutamate	αCH, βCH2, γCH2	3.75(m), 2.12(m), 2.35(m)	P
59	methionine	αCH, βCH2, γCH2, S-CH3	3.87(t), 2.16(m), 2.65(t), 2.14(s)	P
60	pyruvate	CH3	2.37(s)	P
61	glutamine	αCH, βCH2, γCH2	3.78(m), 2.14(m), 2.45(m)	P
62	glycerolphosphocholine	CH3, βCH2, αCH2	3.22(s), 3.69(t), 4.33(t)	P
63	phosphorylcholine	N(CH3)3, OCH2, NCH2	3.22(s), 4.21(t), 3.61(t)	P
64	myo-inositol	1,3-CH, 2-CH, 5-CH, 4,6-CH	3.60(dd), 4.06(t), 3.30(t), 3.63(t)	P
65	threonine	αCH, βCH, γCH3	3.58(d), 4.24(m), 1.32(d)	P
66	unsaturated lipids	= CH-CH2C =, -CH = CH-	5.19 (m), 5.30(m)	P
67	tyrosine	2,6-CH, 3,5-CH	7.20(dd), 6.91(d)	P
68	1-methylhistidine	4-CH, 2-CH	7.05(s), 7.78(s)	P
69	phenylalanine	2,6-CH, 3,5-CH, 4-CH	7.32(m), 7.42(m), 7.37(m)	P
70	3-methylhistidine	4-CH, 2-CH	7.07(s), 7.67(s)	P

^a U, urine; P, plasma;

* HDL, high density lipoprotein; LDL, low density lipoprotein; VLDL, very low density lipoprotein; s, singlet; d, doublet; t, triplet; q, quartet; dd, doublet of doublets; m, multiplet

Further, there is an error in the footnotes for Table 5. VLDL stands for “very low density lipoprotein,” not “low density lipoprotein.” Please view the complete, correct Table 5 footnotes below.