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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Structure. 2015 Feb 5;23(3):441–449. doi: 10.1016/j.str.2014.12.014

Figure 1. Sequence alignment of VHL BC box and cullin box to other Cul2 and Cul5 binding proteins.

Figure 1

The regions for the BC box and cullin box are marked. Conserved residues are highlighted and the Φp (Φ indicates a hydrophobic residue) motif is shown. VHL missense mutations associated with VHL disease are shown in red.