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. Author manuscript; available in PMC: 2016 Mar 4.
Published in final edited form as: Neuron. 2015 Feb 19;85(5):1056–1069. doi: 10.1016/j.neuron.2015.01.024

Figure 4. Homeostatic Modulation of Readily-Releasable Vesicle Pool Size is Absent in rbp Mutants.

Figure 4

(A) Peak EPSC amplitudes (top), and cumulative EPSC amplitudes (‘cum. EPSC’; bottom) during 60-Hz stimulation of representative synapses of the indicated genotypes in the absence (left) and presence (right) of PhTX at 15 mM [Ca2+]e.

(B) Average mEPSP amplitudes (left), cumulative EPSC amplitudes (middle), and normalized readily-releasable pool sizes (‘RRP’, right; see Experimental Procedures) of the indicated genotypes and conditions. wt (−PhTX): n=5; wt (+PhTX): n=7; drbp (−PhTX): n=9; drbp (+PhTX): n=12. PhTX application induces no significant change in cumulative EPSC amplitude in wild type (p=0.2), and a significant decrease in cumulative EPSC amplitude in drbp (p<0.001), indicating a block in the homeostatic increase in RRP size in drbp.