Table 2.
Comparison of histological tumor type and FISH results.
| Histological diagnosis | Total | MDM+ | MDM− | MDM2−, with multiple copies of CEP12 and MDM2 signals |
|---|---|---|---|---|
| Benign | 122 | 9 | 113 | 20 |
| Lipoma | 76 | 4 | 72 | 9 |
| Intramuscular lipoma | 12 | 2 | 10 | 0 |
| Spindle cell lipoma | 17 | 0 | 17 | 5 |
| Pleomorphic lipoma | 9 | 2 | 7 | 5 |
| Fat necrosis | 2 | 0 | 2 | 0 |
| Lipoblastoma | 2 | 0 | 2 | 0 |
| Lipoleiomyoma | 1 | 0 | 1 | 1 |
| Hibernoma | 1 | 0 | 1 | 0 |
| Nevus lipomatosis | 1 | 0 | 1 | 0 |
| Fibroadipose tissue/scar | 2 | 1 | 1 | 0 |
| Liposarcoma | 145 | 137 | 8 | 10 |
| WDL | 73 | 71 | 2 | 5 |
| DDL | 69 | 66 | 3 | 3 |
| Myxoid LPS | 2 | 0 | 2 | 0 |
| Pleomorphic LPS | 1 | 0 | 1 | 2 |
| Equivocal cases | 34 (including 1 technical fail) | 10 | 23 | 0 |
| Possible WDL/DDL | 19 | 6 | 13 | 0 |
| Probable/suspected WDL/DDL | 15 | 4 | 10 | 0 |
| Other soft tissue sarcomas/malignancies | 64 (including 2 technical fails) | 14 | 48 | 26 |
| Undifferentiated pleomorphic sarcoma | 28 | 5 | 21 | 14 |
| Spindle cell sarcoma (NOS) | 19 | 2 | 17 | 8 |
| Rhabdomyosarcoma | 5 | 3 | 2 | 2 |
| Solitary fibrous tumor | 3 | 1 | 2 | 1 |
| Leiomyosarcoma | 3 | 1 | 2 | 1 |
| Malignant peripheral nerve sheath tumor | 2 | 1 | 1 | 0 |
| Osteosarcoma | 1 | 1 | 0 | 0 |
| Inflammatory myofibroblastic tumor | 1 | 0 | 1 | 0 |
| Poorly differentiated carcinoma | 2 | 0 | 2 | 0 |