Abstract
The effect of 6 days' s.c. infusions of angiotensin II at increasing doses was determined on the uptake of rat or human low density lipoprotein (LDL) and of human fibrinogen by aorta in normal and spontaneously hypertensive rats. Rat or human LDL or human fibrinogen was injected i.v. 5 days after the start of infusion, and 24 hr later the radioactivity of aortic walls was determined. Body weight was almost constant in control rats and moderately decreased in a dose-dependent way by angiotensin II. Diastolic blood pressure decreased slightly over 6 days in control rats and increased transiently at the lowest dose of angiotensin II and progressively with two higher concentrations. All three angiotensin II concentrations significantly increased the uptake of rat and human LDL and of fibrinogen by aorta. The increase was dose related for rat LDL but not for human LDL or fibrinogen. In spontaneously hypertensive rats of the same age in which blood pressure was higher than in angiotensin II-infused rats, protein uptakes were not increased. The blood content of aortic walls was negligible and not altered by angiotensin II. Therefore, the uptake of atherogenic plasma proteins by rat aorta is increased by angiotensin II, but this effect may be independent of its pressor action.
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- Assreuy J., Moncada S. A perfusion system for the long term study of macrophage activation. Br J Pharmacol. 1992 Oct;107(2):317–321. doi: 10.1111/j.1476-5381.1992.tb12744.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cardona-Sanclemente L. E., Born G. V. Adrenaline increases the uptake of low-density lipoproteins in carotid arteries of rabbits. Atherosclerosis. 1992 Oct;96(2-3):215–218. doi: 10.1016/0021-9150(92)90067-q. [DOI] [PubMed] [Google Scholar]
- Cardona-Sanclemente L. E., Ferezou J., Lutton C. Cholesterol metabolism in the genetically hypercholesterolemic (RICO) rat. II. A study of plasma lipoproteins and effect of dietary cholesterol. Biochim Biophys Acta. 1988 Jun 15;960(3):382–389. doi: 10.1016/0005-2760(88)90046-x. [DOI] [PubMed] [Google Scholar]
- Fidge N. H., Poulis P. Metabolic heterogeneity in the formation of low density lipoprotein from very low density lipoprotein in the rat: evidence for the independent production of a low density lipoprotein subfraction. J Lipid Res. 1978 Mar;19(3):342–349. [PubMed] [Google Scholar]
- GRAY S. J., STERLING K. The tagging of red cells and plasma proteins with radioactive chromium. J Clin Invest. 1950 Dec;29(12):1604–1613. doi: 10.1172/JCI102403. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAVEL R. J., EDER H. A., BRAGDON J. H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955 Sep;34(9):1345–1353. doi: 10.1172/JCI103182. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koga S., Horwitz D. L., Scanu A. M. Isolation and properties of lipoproteins from normal rat serum. J Lipid Res. 1969 Sep;10(5):577–588. [PubMed] [Google Scholar]
- Pittman R. C., Carew T. E., Glass C. K., Green S. R., Taylor C. A., Jr, Attie A. D. A radioiodinated, intracellularly trapped ligand for determining the sites of plasma protein degradation in vivo. Biochem J. 1983 Jun 15;212(3):791–800. doi: 10.1042/bj2120791. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Recommended methods for radioisotope red-cell survival studies. A report by the ICSH panel on diagnostic applications of radioisotopes in haematology. Br J Haematol. 1971 Aug;21(2):241–250. doi: 10.1111/j.1365-2141.1971.tb03435.x. [DOI] [PubMed] [Google Scholar]
- Shafi S., Cusack N. J., Born G. V. Increased uptake of methylated low-density lipoprotein induced by noradrenaline in carotid arteries of anaesthetized rabbits. Proc R Soc Lond B Biol Sci. 1989 Jan 23;235(1281):289–298. doi: 10.1098/rspb.1989.0001. [DOI] [PubMed] [Google Scholar]