Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Apr 12;91(8):3304–3308. doi: 10.1073/pnas.91.8.3304

Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.

V E Koliatsos 1, M H Cayouette 1, L R Berkemeier 1, R E Clatterbuck 1, D L Price 1, A Rosenthal 1
PMCID: PMC43565  PMID: 8159743

Abstract

The survival of developing motor neurons depends on factors secreted from skeletal muscles and from cells within the central nervous system. Although several members of the nerve growth factor protein family [neurotrophins (NTs)] are able to maintain developing rat motor neurons in vitro, only the brain-derived neurotrophic factor has been shown to have significant effects on the survival of motor neurons in vivo. In the present study, we demonstrate that NT-4/5 also prevents injury-induced death of facial motor neurons in neonatal rats. Furthermore, facial motor neurons express a functional receptor for NT-4/5, whereas mRNA-encoding NT-4/5 can be detected in their environment throughout embryonic and postnatal life. Thus, both NT-4/5 and brain-derived neurotrophic factor may be physiological survival factors for facial motor neurons and may serve as therapeutic agents for motor neuron disease.

Full text

PDF
3304

Images in this article

3305Image
on p.3305
3306Image
on p.3306
3306Image
on p.3306
3307Image
on p.3307
3307Image
on p.3307

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appel S. H., McManaman J. L., Oppenheim R., Haverkamp L., Vaca K. Muscle-derived trophic factors influencing cholinergic neurons in vitro and in vivo. Prog Brain Res. 1989;79:251–256. doi: 10.1016/s0079-6123(08)62484-x. [DOI] [PubMed] [Google Scholar]
  2. Arakawa Y., Sendtner M., Thoenen H. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J Neurosci. 1990 Nov;10(11):3507–3515. doi: 10.1523/JNEUROSCI.10-11-03507.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berkemeier L. R., Winslow J. W., Kaplan D. R., Nikolics K., Goeddel D. V., Rosenthal A. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron. 1991 Nov;7(5):857–866. doi: 10.1016/0896-6273(91)90287-a. [DOI] [PubMed] [Google Scholar]
  4. Bloch-Gallego E., Huchet M., el M'Hamdi H., Xie F. K., Tanaka H., Henderson C. E. Survival in vitro of motoneurons identified or purified by novel antibody-based methods is selectively enhanced by muscle-derived factors. Development. 1991 Jan;111(1):221–232. doi: 10.1242/dev.111.1.221. [DOI] [PubMed] [Google Scholar]
  5. Dechant G., Rodríguez-Tébar A., Kolbeck R., Barde Y. A. Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons. J Neurosci. 1993 Jun;13(6):2610–2616. doi: 10.1523/JNEUROSCI.13-06-02610.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dohrmann U., Edgar D., Sendtner M., Thoenen H. Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture. Dev Biol. 1986 Nov;118(1):209–221. doi: 10.1016/0012-1606(86)90089-8. [DOI] [PubMed] [Google Scholar]
  7. Dohrmann U., Edgar D., Thoenen H. Distinct neurotrophic factors from skeletal muscle and the central nervous system interact synergistically to support the survival of cultured embryonic spinal motor neurons. Dev Biol. 1987 Nov;124(1):145–152. doi: 10.1016/0012-1606(87)90467-2. [DOI] [PubMed] [Google Scholar]
  8. Escandón E., Burton L. E., Szönyi E., Nikolics K. Characterization of neurotrophin receptors by affinity crosslinking. J Neurosci Res. 1993 Apr 15;34(6):601–613. doi: 10.1002/jnr.490340602. [DOI] [PubMed] [Google Scholar]
  9. Henderson C. E., Camu W., Mettling C., Gouin A., Poulsen K., Karihaloo M., Rullamas J., Evans T., McMahon S. B., Armanini M. P. Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature. 1993 May 20;363(6426):266–270. doi: 10.1038/363266a0. [DOI] [PubMed] [Google Scholar]
  10. Hollyday M., Hamburger V. Reduction of the naturally occurring motor neuron loss by enlargement of the periphery. J Comp Neurol. 1976 Dec 1;170(3):311–320. doi: 10.1002/cne.901700304. [DOI] [PubMed] [Google Scholar]
  11. Ip N. Y., Ibáez C. F., Nye S. H., McClain J., Jones P. F., Gies D. R., Belluscio L., Le Beau M. M., Espinosa R., 3rd, Squinto S. P. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3060–3064. doi: 10.1073/pnas.89.7.3060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Klein R., Conway D., Parada L. F., Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 1990 May 18;61(4):647–656. doi: 10.1016/0092-8674(90)90476-u. [DOI] [PubMed] [Google Scholar]
  13. Koliatsos V. E., Clatterbuck R. E., Winslow J. W., Cayouette M. H., Price D. L. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron. 1993 Mar;10(3):359–367. doi: 10.1016/0896-6273(93)90326-m. [DOI] [PubMed] [Google Scholar]
  14. Middlemas D. S., Lindberg R. A., Hunter T. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol. 1991 Jan;11(1):143–153. doi: 10.1128/mcb.11.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Oppenheim R. W., Yin Q. W., Prevette D., Yan Q. Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature. 1992 Dec 24;360(6406):755–757. doi: 10.1038/360755a0. [DOI] [PubMed] [Google Scholar]
  16. Sendtner M., Holtmann B., Kolbeck R., Thoenen H., Barde Y. A. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature. 1992 Dec 24;360(6406):757–759. doi: 10.1038/360757a0. [DOI] [PubMed] [Google Scholar]
  17. Smith R. G., Vaca K., McManaman J., Appel S. H. Selective effects of skeletal muscle extract fractions on motoneuron development in vitro. J Neurosci. 1986 Feb;6(2):439–447. doi: 10.1523/JNEUROSCI.06-02-00439.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yan Q., Elliott J., Snider W. D. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature. 1992 Dec 24;360(6406):753–755. doi: 10.1038/360753a0. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES