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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Hypertension. 2015 Feb 17;65(4):800–805. doi: 10.1161/HYPERTENSIONAHA.115.05166

Figure 1. Disulfide bridged AGT is the only form in mouse plasma.

Figure 1

Western blotting was performed in plasma samples from mice prior to (A and B) or 2 weeks post (C) AAV injections. Plasma samples were incubated without mPEG or with mPEG (5 kDa) for cysteine attachment. Disulfide bridged AGT and mutated AGT (Cys18Ser, Cys137Ser) gained molecular weight by 10 kDa due to addition of 2 mPEG to free Cys300 and Cys316. WT represents wild-type AGT AAV.